The demand for metals and other natural resources is surging and, in some instances, demand has already outstripped supply. Discovery of new deposits or the exploitation of known lower-grade ore deposits could offer solutions, but their implementation is not always straightforward, given political constraints and the complexities of international trade. This focus issue brings together a collection of review articles and opinion pieces that highlight the emerging science of the processes responsible for the formation of economic-grade ore deposits, and discuss the societal conditions and implications of their exploitation.