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June 1996
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volume 13 number 2 page 161
A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
C.L. Hanis1, E. Boerwinkle1, R. Chakraborty1, D.L. Ellsworth1, P. Concannon2, B. Stirling2, V.A. Morrison2, B. Wapelhorst2, R.S. Spielman3, K.J. Gogolin-Ewens3, J.M. Shephard3, S.R. Williams3, N. Risch4, D. Hinds4, N. Iwasaki5, M. Ogata5, Y. Omori5, C. Petzold6, H. Rietzsch6, H.-E. Schr�der6, J. Schulze6, N.J. Cox7, S. Menzel7, V.V. Boriraj7, X. Chen7, L.R. Lim7, T. Lindner7, L.E. Mereu7, Y.-Q. Wang7, K. Xiang7, K. Yamagata7, Y. Yang7 & G.I. Bell7
Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non- and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1.
1Human Genetics Center, The University of Texas Health Science Center at Houston, P.O. Box 20334, Houston, Texas 77030, USA
2Virginia Mason Research Center, Seattle, Washington 98101, and Department of Immunology, University of Washington, Seattle, Washington 98195, USA
3Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
4Department of Genetics, Stanford University, Stanford, California 94305-5120, USA
5Diabetes Center, Tokyo Women�s Medical College, Tokyo 162, Japan
6Department of Internal Medicine III, University Clinic Carl Gustav Carus of the Technical University, Dresden, Germany
7HHMI and Departments of Biochemistry and Molecular Biology, and Medicine, The University of Chicago, 5841 South Maryland Avenue, MC1028, Chicago, Illinois 60637, USA
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