Top 10
The top ten charts the articles that have been downloaded most often, in PDF format, from the Nature Genetics website in recent weeks. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.
Top of pageArticle
Widespread microRNA repression by Myc contributes to tumorigenesis
Tsung-Cheng Chang, Duonan Yu, Yun-Sil Lee, Erik A Wentzel, Dan E Arking, Kristin M West, Chi V Dang, Andrei Thomas-Tikhonenko & Joshua T Mendell
doi:10.1038/ng.2007.30
Abstract - Widespread microRNA repression by Myc contributes to tumorigenesis | Full Text - Widespread microRNA repression by Myc contributes to tumorigenesis | PDF (693 KB) - Widespread microRNA repression by Myc contributes to tumorigenesis | Supplementary information - Widespread microRNA repression by Myc contributes to tumorigenesis
News and Views
Copy-number analysis goes more than skin deep
Steven A McCarroll
doi:10.1038/ng0108-5
Abstract - | Full Text - Copy-number analysis goes more than skin deep | PDF (187 KB) - Copy-number analysis goes more than skin deep
See also: Brief Communication by Hollox et al.
Perspective
The emerging landscape of breast cancer susceptibility
Michael R Stratton & Nazneen Rahman
doi:10.1038/ng.2007.53
Abstract - The emerging landscape of breast cancer susceptibility | Full Text - The emerging landscape of breast cancer susceptibility | PDF (298 KB) - The emerging landscape of breast cancer susceptibility
Letter
Genome-wide analysis of transcript isoform variation in humans
Tony Kwan, David Benovoy, Christel Dias, Scott Gurd, Cathy Provencher, Patrick Beaulieu, Thomas J Hudson, Rob Sladek & Jacek Majewski
doi:10.1038/ng.2007.57
Abstract - Genome-wide analysis of transcript isoform variation in humans | Full Text - Genome-wide analysis of transcript isoform variation in humans | PDF (390 KB) - Genome-wide analysis of transcript isoform variation in humans | Supplementary information - Genome-wide analysis of transcript isoform variation in humans
Article
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Cristen J Willer, Serena Sanna, Anne U Jackson, Angelo Scuteri, Lori L Bonnycastle, Robert Clarke, Simon C Heath, Nicholas J Timpson, Samer S Najjar, Heather M Stringham, James Strait, William L Duren, Andrea Maschio, Fabio Busonero, Antonella Mulas, Giuseppe Albai, Amy J Swift, Mario A Morken, Narisu Narisu, Derrick Bennett, Sarah Parish, Haiqing Shen, Pilar Galan, Pierre Meneton, Serge Hercberg, Diana Zelenika, Wei-Min Chen, Yun Li, Laura J Scott, Paul A Scheet, Jouko Sundvall, Richard M Watanabe, Ramaiah Nagaraja, Shah Ebrahim, Debbie A Lawlor, Yoav Ben-Shlomo, George Davey-Smith, Alan R Shuldiner, Rory Collins, Richard N Bergman, Manuela Uda, Jaakko Tuomilehto, Antonio Cao, Francis S Collins, Edward Lakatta, G Mark Lathrop, Michael Boehnke, David Schlessinger, Karen L Mohlke & Gonçalo R Abecasis
doi:10.1038/ng.76
Abstract - Newly identified loci that influence lipid concentrations and risk of coronary artery disease | Full Text - Newly identified loci that influence lipid concentrations and risk of coronary artery disease | PDF (422 KB) - Newly identified loci that influence lipid concentrations and risk of coronary artery disease | Supplementary information - Newly identified loci that influence lipid concentrations and risk of coronary artery disease
See also: News and Views by Lusis & Pajukanta | Brief Communication by Kooner et al. | Letter by Kathiresan et al.
Brief Communication
Psoriasis is associated with increased
-defensin genomic copy number Edward J Hollox, Ulrike Huffmeier, Patrick L J M Zeeuwen, Raquel Palla, Jesús Lascorz, Diana Rodijk-Olthuis, Peter C M van de Kerkhof, Heiko Traupe, Gys de Jongh, Martin den Heijer, André Reis, John A L Armour & Joost Schalkwijk
doi:10.1038/ng.2007.48
Abstract - Psoriasis is associated with increased
-defensin genomic copy number | Full Text - Psoriasis is associated with increased -defensin genomic copy number | PDF (173 KB) - Psoriasis is associated with increased -defensin genomic copy number | Supplementary information - Psoriasis is associated with increased -defensin genomic copy numberSee also: News and Views by McCarroll
Analysis
Epigenetic regulation and the variability of gene expression
Jung Kyoon Choi & Young-Joon Kim
doi:10.1038/ng.2007.58
Abstract - Epigenetic regulation and the variability of gene expression | Full Text - Epigenetic regulation and the variability of gene expression | PDF (3,420 KB) - Epigenetic regulation and the variability of gene expression | Supplementary information - Epigenetic regulation and the variability of gene expression
Article
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
Julián Aragonés, Martin Schneider, Katie Van Geyte, Peter Fraisl, Tom Dresselaers, Massimiliano Mazzone, Ruud Dirkx, Serena Zacchigna, Hélène Lemieux, Nam Ho Jeoung, Diether Lambrechts, Tammie Bishop, Peggy Lafuste, Antonio Diez-Juan, Sarah K Harten, Pieter Van Noten, Katrien De Bock, Carsten Willam, Marc Tjwa, Alexandra Grosfeld, Rachel Navet, Lieve Moons, Thierry Vandendriessche, Christophe Deroose, Bhathiya Wijeyekoon, Johan Nuyts, Benedicte Jordan, Robert Silasi-Mansat, Florea Lupu, Mieke Dewerchin, Chris Pugh, Phil Salmon, Luc Mortelmans, Bernard Gallez, Frans Gorus, Johan Buyse, Francis Sluse, Robert A Harris, Erich Gnaiger, Peter Hespel, Paul Van Hecke, Frans Schuit, Paul Van Veldhoven, Peter Ratcliffe, Myriam Baes, Patrick Maxwell & Peter Carmeliet
doi:10.1038/ng.2007.62
Abstract - Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism | Full Text - Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism | PDF (1,010 KB) - Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism | Supplementary information - Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
See also: News and Views by Kelly
News and Views
Genomic rearrangements in the spotlight
Lucy R Osborne
doi:10.1038/ng0108-6
Abstract - | Full Text - Genomic rearrangements in the spotlight | PDF (215 KB) - Genomic rearrangements in the spotlight
See also: Letter by Turner et al.
Letter
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Sekar Kathiresan, Olle Melander, Candace Guiducci, Aarti Surti, Noël P Burtt, Mark J Rieder, Gregory M Cooper, Charlotta Roos, Benjamin F Voight, Aki S Havulinna, Björn Wahlstrand, Thomas Hedner, Dolores Corella, E Shyong Tai, Jose M Ordovas, Göran Berglund, Erkki Vartiainen, Pekka Jousilahti, Bo Hedblad, Marja-Riitta Taskinen, Christopher Newton-Cheh, Veikko Salomaa, Leena Peltonen, Leif Groop, David M Altshuler & Marju Orho-Melander
doi:10.1038/ng.75
Abstract - Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans | Full Text - Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans | PDF (334 KB) - Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans | Supplementary information - Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
See also: News and Views by Lusis & Pajukanta | Brief Communication by Kooner et al. | Article by Willer et al.