Latest Research

  • Letter |

    A genome-wide study identifies common variation near IRF6 associated with liver injury induced by IFN-β in individuals treated for multiple sclerosis. The risk locus is associated with differential expression of IRF6 and may help guide safer use of this biologic.

    • Kaarina Kowalec
    • , Galen E. B. Wright
    • , Britt I. Drögemöller
    • , Folefac Aminkeng
    • , Amit P. Bhavsar
    • , Elaine Kingwell
    • , Eric M. Yoshida
    • , Anthony Traboulsee
    • , Ruth Ann Marrie
    • , Marcelo Kremenchutzky
    • , Trudy L. Campbell
    • , Pierre Duquette
    • , Naga Chalasani
    • , Mia Wadelius
    • , Pär Hallberg
    • , Zongqi Xia
    • , Philip L. De Jager
    • , Joshua C. Denny
    • , Mary F. Davis
    • , Colin J. D. Ross
    • , Helen Tremlett
    •  & Bruce C. Carleton
  • Letter |

    High levels of fumarate or succinate suppress the homologous-recombination DNA-repair pathway in cancer cells that are deficient for FH or SDH, respectively. These tumor cells are vulnerable to PARP inhibitors.

    • Parker L. Sulkowski
    • , Ranjini K. Sundaram
    • , Sebastian Oeck
    • , Christopher D. Corso
    • , Yanfeng Liu
    • , Seth Noorbakhsh
    • , Monica Niger
    • , Marta Boeke
    • , Daiki Ueno
    • , Aravind Nambiar Kalathil
    • , Xun Bao
    • , Jing Li
    • , Brian Shuch
    • , Ranjit S. Bindra
    •  & Peter M. Glazer
  • Letter |

    Biallelic truncating mutations in CTNNA2, encoding αN-catenin, cause a new pachygyria syndrome associated with actin regulation and ARP2 and ARP3 repression in neurons.

    • Ashleigh E. Schaffer
    • , Martin W. Breuss
    • , Ahmet Okay Caglayan
    • , Nouriya Al-Sanaa
    • , Hind Y. Al-Abdulwahed
    • , Hande Kaymakçalan
    • , Cahide Yılmaz
    • , Maha S. Zaki
    • , Rasim O. Rosti
    • , Brett Copeland
    • , Seung Tae Baek
    • , Damir Musaev
    • , Eric C. Scott
    • , Tawfeg Ben-Omran
    • , Ariana Kariminejad
    • , Hulya Kayserili
    • , Faezeh Mojahedi
    • , Majdi Kara
    • , Na Cai
    • , Jennifer L. Silhavy
    • , Seham Elsharif
    • , Elif Fenercioglu
    • , Bruce A. Barshop
    • , Bulent Kara
    • , Rengang Wang
    • , Valentina Stanley
    • , Kiely N. James
    • , Rahul Nachnani
    • , Aneesha Kalur
    • , Hisham Megahed
    • , Faruk Incecik
    • , Sumita Danda
    • , Yasemin Alanay
    • , Eissa Faqeih
    • , Gia Melikishvili
    • , Lobna Mansour
    • , Ian Miller
    • , Biayna Sukhudyan
    • , Jamel Chelly
    • , William B. Dobyns
    • , Kaya Bilguvar
    • , Rami Abou Jamra
    • , Murat Gunel
    •  & Joseph G. Gleeson
  • Article |

    A high-throughput method for functional SNP identification uses enzymatic restriction to detect altered regulatory protein binding and identifies 148 candidate fSNPs associated with juvenile idiopathic arthritis, including two that regulate STAT4 via the regulatory proteins SATB2 and H1.2.

    • Gang Li
    • , Marta Martínez-Bonet
    • , Di Wu
    • , Yu Yang
    • , Jing Cui
    • , Hung N. Nguyen
    • , Pierre Cunin
    • , Anaïs Levescot
    • , Ming Bai
    • , Harm-Jan Westra
    • , Yukinori Okada
    • , Michael B. Brenner
    • , Soumya Raychaudhuri
    • , Eric A. Hendrickson
    • , Richard L. Maas
    •  & Peter A. Nigrovic
  • Letter |

    Genome-wide association analyses identify new risk loci for allergic rhinitis and for sensitization to inhalant allergens. The associated regions implicate immune-related pathways, including innate and adaptive IgE-related mechanisms.

    • Johannes Waage
    • , Marie Standl
    • , John A. Curtin
    • , Leon E. Jessen
    • , Jonathan Thorsen
    • , Chao Tian
    • , Nathan Schoettler
    • , Carlos Flores
    • , Abdel Abdellaoui
    • , Tarunveer S. Ahluwalia
    • , Alexessander C. Alves
    • , Andre F. S. Amaral
    • , Josep M. Antó
    • , Andreas Arnold
    • , Amalia Barreto-Luis
    • , Hansjörg Baurecht
    • , Catharina E. M. van Beijsterveldt
    • , Eugene R. Bleecker
    • , Sílvia Bonàs-Guarch
    • , Dorret I. Boomsma
    • , Susanne Brix
    • , Supinda Bunyavanich
    • , Esteban G. Burchard
    • , Zhanghua Chen
    • , Ivan Curjuric
    • , Adnan Custovic
    • , Herman T. den Dekker
    • , Shyamali C. Dharmage
    • , Julia Dmitrieva
    • , Liesbeth Duijts
    • , Markus J. Ege
    • , W. James Gauderman
    • , Michel Georges
    • , Christian Gieger
    • , Frank Gilliland
    • , Raquel Granell
    • , Hongsheng Gui
    • , Torben Hansen
    • , Joachim Heinrich
    • , John Henderson
    • , Natalia Hernandez-Pacheco
    • , Patrick Holt
    • , Medea Imboden
    • , Vincent W. V. Jaddoe
    • , Marjo-Riitta Jarvelin
    • , Deborah L. Jarvis
    • , Kamilla K. Jensen
    • , Ingileif Jónsdóttir
    • , Michael Kabesch
    • , Jaakko Kaprio
    • , Ashish Kumar
    • , Young-Ae Lee
    • , Albert M. Levin
    • , Xingnan Li
    • , Fabian Lorenzo-Diaz
    • , Erik Melén
    • , Josep M. Mercader
    • , Deborah A. Meyers
    • , Rachel Myers
    • , Dan L. Nicolae
    • , Ellen A. Nohr
    • , Teemu Palviainen
    • , Lavinia Paternoster
    • , Craig E. Pennell
    • , Göran Pershagen
    • , Maria Pino-Yanes
    • , Nicole M. Probst-Hensch
    • , Franz Rüschendorf
    • , Angela Simpson
    • , Kari Stefansson
    • , Jordi Sunyer
    • , Gardar Sveinbjornsson
    • , Elisabeth Thiering
    • , Philip J. Thompson
    • , Maties Torrent
    • , David Torrents
    • , Joyce Y. Tung
    • , Carol A. Wang
    • , Stephan Weidinger
    • , Scott Weiss
    • , Gonneke Willemsen
    • , L. Keoki Williams
    • , Carole Ober
    • , David A. Hinds
    • , Manuel A. Ferreira
    • , Hans Bisgaard
    • , David P. Strachan
    •  & Klaus Bønnelykke
  • Analysis |

    The authors identify whole-genome doubling (WGD) in 30% of ~10,000 sequenced tumors from patients with advanced cancer. WGD correlates with increased risk of death across cancer types.

    • Craig M. Bielski
    • , Ahmet Zehir
    • , Alexander V. Penson
    • , Mark T. A. Donoghue
    • , Walid Chatila
    • , Joshua Armenia
    • , Matthew T. Chang
    • , Alison M. Schram
    • , Philip Jonsson
    • , Chaitanya Bandlamudi
    • , Pedram Razavi
    • , Gopa Iyer
    • , Mark E. Robson
    • , Zsofia K. Stadler
    • , Nikolaus Schultz
    • , Jose Baselga
    • , David B. Solit
    • , David M. Hyman
    • , Michael F. Berger
    •  & Barry S. Taylor
  • Article |

    Analysis of ATAC-seq and RNA-seq data from stimulated T cells identifies genetic variants that disrupt transcription factor binding sites within ATAC-seq peaks. ATAC quantitative trait loci (ATAC-QTLs) are enriched for autoimmune disease-associated variants.

    • Rachel E. Gate
    • , Christine S. Cheng
    • , Aviva P. Aiden
    • , Atsede Siba
    • , Marcin Tabaka
    • , Dmytro Lituiev
    • , Ido Machol
    • , M. Grace Gordon
    • , Meena Subramaniam
    • , Muhammad Shamim
    • , Kendrick L. Hougen
    • , Ivo Wortman
    • , Su-Chen Huang
    • , Neva C. Durand
    • , Ting Feng
    • , Philip L. De Jager
    • , Howard Y. Chang
    • , Erez Lieberman Aiden
    • , Christophe Benoist
    • , Michael A. Beer
    • , Chun J. Ye
    •  & Aviv Regev
  • Article |

    Multi-contact 4C (MC-4C) sequencing analyzes multi-way conformations of individual alleles. MC-4C identifies the β-globin superenhancer as a hub that can accommodate two genes simultaneously and shows that CTCF-anchored loops collide in WAPL-depleted cells.

    • Amin Allahyar
    • , Carlo Vermeulen
    • , Britta A. M. Bouwman
    • , Peter H. L. Krijger
    • , Marjon J. A. M. Verstegen
    • , Geert Geeven
    • , Melissa van Kranenburg
    • , Mark Pieterse
    • , Roy Straver
    • , Judith H. I. Haarhuis
    • , Kees Jalink
    • , Hans Teunissen
    • , Ivo J. Renkens
    • , Wigard P. Kloosterman
    • , Benjamin D. Rowland
    • , Elzo de Wit
    • , Jeroen de Ridder
    •  & Wouter de Laat
  • Article | | open

    The assembly of the genome of the koala provides insights into its adaptive biology and identifies gene expansions that contribute to its ability to detoxify eucalyptus-derived compounds and perceive plant secondary metabolites.

    • Rebecca N. Johnson
    • , Denis O’Meally
    • , Zhiliang Chen
    • , Graham J. Etherington
    • , Simon Y. W. Ho
    • , Will J. Nash
    • , Catherine E. Grueber
    • , Yuanyuan Cheng
    • , Camilla M. Whittington
    • , Siobhan Dennison
    • , Emma Peel
    • , Wilfried Haerty
    • , Rachel J. O’Neill
    • , Don Colgan
    • , Tonia L. Russell
    • , David E. Alquezar-Planas
    • , Val Attenbrow
    • , Jason G. Bragg
    • , Parice A. Brandies
    • , Amanda Yoon-Yee Chong
    • , Janine E. Deakin
    • , Federica Di Palma
    • , Zachary Duda
    • , Mark D. B. Eldridge
    • , Kyle M. Ewart
    • , Carolyn J. Hogg
    • , Greta J. Frankham
    • , Arthur Georges
    • , Amber K. Gillett
    • , Merran Govendir
    • , Alex D. Greenwood
    • , Takashi Hayakawa
    • , Kristofer M. Helgen
    • , Matthew Hobbs
    • , Clare E. Holleley
    • , Thomas N. Heider
    • , Elizabeth A. Jones
    • , Andrew King
    • , Danielle Madden
    • , Jennifer A. Marshall Graves
    • , Katrina M. Morris
    • , Linda E. Neaves
    • , Hardip R. Patel
    • , Adam Polkinghorne
    • , Marilyn B. Renfree
    • , Charles Robin
    • , Ryan Salinas
    • , Kyriakos Tsangaras
    • , Paul D. Waters
    • , Shafagh A. Waters
    • , Belinda Wright
    • , Marc R. Wilkins
    • , Peter Timms
    •  & Katherine Belov
  • Article |

    Integration of expression quantitative trait locus (eQTL) data from the Genotype-Tissue Expression project with genome-wide association study data shows that eQTLs are enriched for trait associations in disease-relevant tissues.

    • Eric R. Gamazon
    • , Ayellet V. Segrè
    • , Martijn van de Bunt
    • , Xiaoquan Wen
    • , Hualin S. Xi
    • , Farhad Hormozdiari
    • , Halit Ongen
    • , Anuar Konkashbaev
    • , Eske M. Derks
    • , François Aguet
    • , Jie Quan
    • , Dan L. Nicolae
    • , Eleazar Eskin
    • , Manolis Kellis
    • , Gad Getz
    • , Mark I. McCarthy
    • , Emmanouil T. Dermitzakis
    • , Nancy J. Cox
    •  & Kristin G. Ardlie
  • Letter |

    Analysis of paralog gene pairs using data from loss-of-function genetic screens in cancer cells identifies MAGOH and MAGOHB as reciprocal paralog dependencies across cancer types.

    • Srinivas R. Viswanathan
    • , Marina F. Nogueira
    • , Colin G. Buss
    • , John M. Krill-Burger
    • , Mathias J. Wawer
    • , Edyta Malolepsza
    • , Ashton C. Berger
    • , Peter S. Choi
    • , Juliann Shih
    • , Alison M. Taylor
    • , Benjamin Tanenbaum
    • , Chandra Sekhar Pedamallu
    • , Andrew D. Cherniack
    • , Pablo Tamayo
    • , Craig A. Strathdee
    • , Kasper Lage
    • , Steven A. Carr
    • , Monica Schenone
    • , Sangeeta N. Bhatia
    • , Francisca Vazquez
    • , Aviad Tsherniak
    • , William C. Hahn
    •  & Matthew Meyerson
  • Letter |

    A meta-analysis of genome-wide association studies for neuroticism identifies novel loci, pathways and potential drug targets. Further analysis implicates specific brain regions and evaluates genetic overlap with other neuropsychiatric traits.

    • Mats Nagel
    • , Philip R. Jansen
    • , Sven Stringer
    • , Kyoko Watanabe
    • , Christiaan A. de Leeuw
    • , Julien Bryois
    • , Jeanne E. Savage
    • , Anke R. Hammerschlag
    • , Nathan G. Skene
    • , Ana B. Muñoz-Manchado
    • , Michelle Agee
    • , Babak Alipanahi
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , David A. Hinds
    • , Bethann S. Hromatka
    • , Karen E. Huber
    • , Aaron Kleinman
    • , Nadia K. Litterman
    • , Matthew H. McIntyre
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , J. Fah Sathirapongsasuti
    • , Olga V. Sazonova
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Catherine H. Wilson
    • , Tonya White
    • , Henning Tiemeier
    • , Sten Linnarsson
    • , Jens Hjerling-Leffler
    • , Tinca J. C. Polderman
    • , Patrick F. Sullivan
    • , Sophie van der Sluis
    •  & Danielle Posthuma
  • Letter |

    Meta-analysis of genome-wide association studies for cognitive ability identifies 190 new loci and implicates 939 new genes related to neurogenesis, neuron differentiation and synaptic structure.

    • Jeanne E. Savage
    • , Philip R. Jansen
    • , Sven Stringer
    • , Kyoko Watanabe
    • , Julien Bryois
    • , Christiaan A. de Leeuw
    • , Mats Nagel
    • , Swapnil Awasthi
    • , Peter B. Barr
    • , Jonathan R. I. Coleman
    • , Katrina L. Grasby
    • , Anke R. Hammerschlag
    • , Jakob A. Kaminski
    • , Robert Karlsson
    • , Eva Krapohl
    • , Max Lam
    • , Marianne Nygaard
    • , Chandra A. Reynolds
    • , Joey W. Trampush
    • , Hannah Young
    • , Delilah Zabaneh
    • , Sara Hägg
    • , Narelle K. Hansell
    • , Ida K. Karlsson
    • , Sten Linnarsson
    • , Grant W. Montgomery
    • , Ana B. Muñoz-Manchado
    • , Erin B. Quinlan
    • , Gunter Schumann
    • , Nathan G. Skene
    • , Bradley T. Webb
    • , Tonya White
    • , Dan E. Arking
    • , Dimitrios Avramopoulos
    • , Robert M. Bilder
    • , Panos Bitsios
    • , Katherine E. Burdick
    • , Tyrone D. Cannon
    • , Ornit Chiba-Falek
    • , Andrea Christoforou
    • , Elizabeth T. Cirulli
    • , Eliza Congdon
    • , Aiden Corvin
    • , Gail Davies
    • , Ian J. Deary
    • , Pamela DeRosse
    • , Dwight Dickinson
    • , Srdjan Djurovic
    • , Gary Donohoe
    • , Emily Drabant Conley
    • , Johan G. Eriksson
    • , Thomas Espeseth
    • , Nelson A. Freimer
    • , Stella Giakoumaki
    • , Ina Giegling
    • , Michael Gill
    • , David C. Glahn
    • , Ahmad R. Hariri
    • , Alex Hatzimanolis
    • , Matthew C. Keller
    • , Emma Knowles
    • , Deborah Koltai
    • , Bettina Konte
    • , Jari Lahti
    • , Stephanie Le Hellard
    • , Todd Lencz
    • , David C. Liewald
    • , Edythe London
    • , Astri J. Lundervold
    • , Anil K. Malhotra
    • , Ingrid Melle
    • , Derek Morris
    • , Anna C. Need
    • , William Ollier
    • , Aarno Palotie
    • , Antony Payton
    • , Neil Pendleton
    • , Russell A. Poldrack
    • , Katri Räikkönen
    • , Ivar Reinvang
    • , Panos Roussos
    • , Dan Rujescu
    • , Fred W. Sabb
    • , Matthew A. Scult
    • , Olav B. Smeland
    • , Nikolaos Smyrnis
    • , John M. Starr
    • , Vidar M. Steen
    • , Nikos C. Stefanis
    • , Richard E. Straub
    • , Kjetil Sundet
    • , Henning Tiemeier
    • , Aristotle N. Voineskos
    • , Daniel R. Weinberger
    • , Elisabeth Widen
    • , Jin Yu
    • , Goncalo Abecasis
    • , Ole A. Andreassen
    • , Gerome Breen
    • , Lene Christiansen
    • , Birgit Debrabant
    • , Danielle M. Dick
    • , Andreas Heinz
    • , Jens Hjerling-Leffler
    • , M. Arfan Ikram
    • , Kenneth S. Kendler
    • , Nicholas G. Martin
    • , Sarah E. Medland
    • , Nancy L. Pedersen
    • , Robert Plomin
    • , Tinca J. C. Polderman
    • , Stephan Ripke
    • , Sophie van der Sluis
    • , Patrick F. Sullivan
    • , Scott I. Vrieze
    • , Margaret J. Wright
    •  & Danielle Posthuma
  • Analysis |

    A new set of functional annotations based on fine-mapped molecular quantitative trait loci from GTEx and BLUEPRINT consortium data are enriched for disease heritability across 41 diseases and complex traits.

    • Farhad Hormozdiari
    • , Steven Gazal
    • , Bryce van de Geijn
    • , Hilary K. Finucane
    • , Chelsea J.-T. Ju
    • , Po-Ru Loh
    • , Armin Schoech
    • , Yakir Reshef
    • , Xuanyao Liu
    • , Luke O’Connor
    • , Alexander Gusev
    • , Eleazar Eskin
    •  & Alkes L. Price
  • Analysis |

    Analysis of individuals with neurodevelopmental disorders (NDDs) with epilepsy identifies 33 genes with a significant excess of de novo variants. Comparison of rates of de novo variants between NDDs with or without epilepsy highlights differences between these phenotypic groups.

    • Henrike O. Heyne
    • , Tarjinder Singh
    • , Hannah Stamberger
    • , Rami Abou Jamra
    • , Hande Caglayan
    • , Dana Craiu
    • , Peter De Jonghe
    • , Renzo Guerrini
    • , Katherine L. Helbig
    • , Bobby P. C. Koeleman
    • , Jack A. Kosmicki
    • , Tarja Linnankivi
    • , Patrick May
    • , Hiltrud Muhle
    • , Rikke S. Møller
    • , Bernd A. Neubauer
    • , Aarno Palotie
    • , Manuela Pendziwiat
    • , Pasquale Striano
    • , Sha Tang
    • , Sitao Wu
    • , Zaid Afawi
    • , Carolien de Kovel
    • , Petia Dimova
    • , Tania Djémié
    • , Milda Endziniene
    • , Dorota Hoffman-Zacharska
    • , Johanna Jähn
    • , Christian Korff
    • , Anna-Elina Lehesjoki
    • , Carla Marini
    • , Stefanie H. Müller
    • , Deb Pal
    • , Niklas Schwarz
    • , Kaja Selmer
    • , Jose Serratosa
    • , Ulrich Stephani
    • , Katalin Štěrbová
    • , Arvid Suls
    • , Steffen Syrbe
    • , Inga Talvik
    • , Shan Tang
    • , Sarah von Spiczak
    • , Federico Zara
    • , Annapurna Poduri
    • , Yvonne G. Weber
    • , Sarah Weckhuysen
    • , Sanjay M. Sisodiya
    • , Mark J. Daly
    • , Ingo Helbig
    • , Dennis Lal
    •  & Johannes R. Lemke
  • Letter |

    Whole-genome sequencing of 303 Vibrio cholerae isolates taken from individuals and households over time in Bangladesh provides insight into the dynamics of cholera diversity and transmission in an endemic setting.

    • Daryl Domman
    • , Fahima Chowdhury
    • , Ashraful I. Khan
    • , Matthew J. Dorman
    • , Ankur Mutreja
    • , Muhammad Ikhtear Uddin
    • , Anik Paul
    • , Yasmin A. Begum
    • , Richelle C. Charles
    • , Stephen B. Calderwood
    • , Taufiqur R. Bhuiyan
    • , Jason B. Harris
    • , Regina C. LaRocque
    • , Edward T. Ryan
    • , Firdausi Qadri
    •  & Nicholas R. Thomson
  • Article |

    This study presents OncoTreat, a framework for the prioritization of compounds targeting mechanistic tumor dependencies in individual patients.

    • Mariano J. Alvarez
    • , Prem S. Subramaniam
    • , Laura H. Tang
    • , Adina Grunn
    • , Mahalaxmi Aburi
    • , Gabrielle Rieckhof
    • , Elena V. Komissarova
    • , Elizabeth A. Hagan
    • , Lisa Bodei
    • , Paul A. Clemons
    • , Filemon S. Dela Cruz
    • , Deepti Dhall
    • , Daniel Diolaiti
    • , Douglas A. Fraker
    • , Afshin Ghavami
    • , Daniel Kaemmerer
    • , Charles Karan
    • , Mark Kidd
    • , Kyoung M. Kim
    • , Hee C. Kim
    • , Lakshmi P. Kunju
    • , Ülo Langel
    • , Zhong Li
    • , Jeeyun Lee
    • , Hai Li
    • , Virginia LiVolsi
    • , Roswitha Pfragner
    • , Allison R. Rainey
    • , Ronald B. Realubit
    • , Helen Remotti
    • , Jakob Regberg
    • , Robert Roses
    • , Anil Rustgi
    • , Antonia R. Sepulveda
    • , Stefano Serra
    • , Chanjuan Shi
    • , Xiaopu Yuan
    • , Massimo Barberis
    • , Roberto Bergamaschi
    • , Arul M. Chinnaiyan
    • , Tony Detre
    • , Shereen Ezzat
    • , Andrea Frilling
    • , Merten Hommann
    • , Dirk Jaeger
    • , Michelle K. Kim
    • , Beatrice S. Knudsen
    • , Andrew L. Kung
    • , Emer Leahy
    • , David C. Metz
    • , Jeffrey W. Milsom
    • , Young S. Park
    • , Diane Reidy-Lagunes
    • , Stuart Schreiber
    • , Kay Washington
    • , Bertram Wiedenmann
    • , Irvin Modlin
    •  & Andrea Califano
  • Technical Report |

    BayesTyper is a new probabilistic genotyping algorithm that offers superior sensitivity and accuracy relative to existing methods by using exact alignment of read k-mers to a graph representation of the reference and candidate variants.

    • Jonas Andreas Sibbesen
    • , Lasse Maretty
    •  & Anders Krogh
  • Article |

    A transcriptome-wide association study identifies associations of genetically predicted gene expression with breast cancer risk. This analysis finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci.

    • Lang Wu
    • , Wei Shi
    • , Jirong Long
    • , Xingyi Guo
    • , Kyriaki Michailidou
    • , Jonathan Beesley
    • , Manjeet K. Bolla
    • , Xiao-Ou Shu
    • , Yingchang Lu
    • , Qiuyin Cai
    • , Fares Al-Ejeh
    • , Esdy Rozali
    • , Qin Wang
    • , Joe Dennis
    • , Bingshan Li
    • , Chenjie Zeng
    • , Helian Feng
    • , Alexander Gusev
    • , Richard T. Barfield
    • , Irene L. Andrulis
    • , Hoda Anton-Culver
    • , Volker Arndt
    • , Kristan J. Aronson
    • , Paul L. Auer
    • , Myrto Barrdahl
    • , Caroline Baynes
    • , Matthias W. Beckmann
    • , Javier Benitez
    • , Marina Bermisheva
    • , Carl Blomqvist
    • , Natalia V. Bogdanova
    • , Stig E. Bojesen
    • , Hiltrud Brauch
    • , Hermann Brenner
    • , Louise Brinton
    • , Per Broberg
    • , Sara Y. Brucker
    • , Barbara Burwinkel
    • , Trinidad Caldés
    • , Federico Canzian
    • , Brian D. Carter
    • , J. Esteban Castelao
    • , Jenny Chang-Claude
    • , Xiaoqing Chen
    • , Ting-Yuan David Cheng
    • , Hans Christiansen
    • , Christine L. Clarke
    • , Margriet Collée
    • , Sten Cornelissen
    • , Fergus J. Couch
    • , David Cox
    • , Angela Cox
    • , Simon S. Cross
    • , Julie M. Cunningham
    • , Kamila Czene
    • , Mary B. Daly
    • , Peter Devilee
    • , Kimberly F. Doheny
    • , Thilo Dörk
    • , Isabel dos-Santos-Silva
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  • Article |

    The roles of of Gorab in the Golgi and in centriole structure and function can be separated mutationally in Drosophila. Complexed to Sas6 in the centriolar cartwheel, Gorab is essential for mitotic centriole duplication in the fly.

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    • , Jennifer Chao-Chu
    • , Sandra Schneider
    • , Marco Gottardo
    • , George Tzolovsky
    • , Nikola S. Dzhindzhev
    • , Maria Giovanna Riparbelli
    • , Giuliano Callaini
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