Meeting program

Forefronts Symposium on Nephrogenetics: from development to physiology

Human genetic disorders directly affecting kidney development and function and mouse models

Suggested reading: www.connotea.org/user/Dicentrarchus0labrax/tag/nephrology

Thursday, March 8, 2007
Time	Detailed Information
17:00	Welcome and Opening Remarks
17:15	Keynote speaker Richard Lifton, Yale University School of Medicine, USA

Friday, March 9, 2007
Time	Detailed Information
09:00	Session 1: Morphogenesis Chair: Cathy Mendelsohn, Columbia University, USA Using zebrafish to explore the genetics of human kidney disease Rebecca Burdine, Princeton University, USA Developmental defects that underlie reflux and urogenital tract obstruction: Revisiting the Bud Theory Cathy Mendelsohn, Columbia University, USA From Precursor to Product: Organogenesis of the Mammalian Kidney Andy McMahon, Harvard University, USA GDNF/Ret signaling and ureteric bud branching morphogenesis Frank Costantini, Columbia University Medical Center, USA
10:45	Coffee & Networking Break
11:15	Session 2: Ion transport Chair: Steven C. Hebert, Yale University School of Medicine, USA Tissue specificity of proton pumps and renal disease Fiona Karet, Cambridge Institute for Medical Research, UK Insights into the Pathophysiology of Antenatal Type II Bartter's Syndrome from the ROMK Knockout Mouse Steven C Hebert, Yale University School of Medicine, USA Regulation Renal Salt and Water Absorption by the Collecting Duct Transcription Factor, PPARgamma Matthew D Breyer, Vanderbilt University Medical Center, USA
12:45	Lunch
14:00	Poster Session & Discussion
14:30	Session 3: Amino acid transport Chair: Robert Kleta, National Human Genome Research Institute, UK Clinical and up-to-date molecular findings in aminoacidurias Robert Kleta, University College London, UK Aminoaciduria nephrogenetics John Rasko, Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, Australia
15:30	Coffee & Networking Break
16:00	Session 4: Renin-angiotensin system Chair: Marie-Claire Gubler, Institut National de la Santé et de la Recherche Médicale, France Autosomal recessive renal tubular dysgenesis and the renin-angiotensin system Marie-Claire Gubler, Institut National de la Santé et de la Recherche Médicale, France Angiotensin II and Epidermal Growth Factor receptor cross-talk in chronic kidney disease Fabiola Terzi, Institut National de la Santé et de la Recherche Médicale, France
17:00	Session 5: Steroid resistant nephrotic syndrome Chair: Corinne Antignac, Institut National de la Santé et de la Recherche Médicale, France Genetics of steroid-resistant nephrotic syndrome Corinne Antignac, Institut National de la Santé et de la Recherche Médicale, France The slit diaphragm protein complex: a protein-lipid supercomplex involved in mechanosensation? Thomas Benzing, University of Cologne, Germany

Saturday, March 10, 2007
Time	Detailed Information
09 :00	Session 6: Cilia / Polycystic Kidney Disease Chair: Heymut Omran, University Hospital Freiburg, Germany HNF1beta in nephrogenesis and tubular planar cell polarisation Marco Pontoglio, Pasteur Institute, France Ciliary Signaling and Polycystic Kidney Disease Jing Zhou, Brigham & Women's Hospital, Harvard Medical School, USA The role of polycystins in renal tubulogenesis Gregory Germino, Johns Hopkins University School of Medicine, USA Intraflagellar Transport (IFT) and Flagellar Assembly: New Insights into the Role of Cilia in Polycystic Kidney Disease (PKD) Joel Rosenbaum, Yale University, USA
10:45	Coffee & Networking Break
11:15	Session 6: Cilia / Polycystic Kidney Disease (continued) Chair: Heymut Omran, University Hospital Freiburg, Germany Mutations in OFD1 and RPGR Responsible for Syndromic Forms of Primary Ciliary Dyskinesia Indicate Functional Properties of Cystoproteins in Motile Cilia Heymut Omran, University Hospital Freiburg, Germany Calcium and cAMP in PKD Cells and Embryonic Kidneys James P. Calvet, University of Kansas Medical Center, USA Treatments for PKD Targeting cAMP Vicente Torres, Mayo Clinic College of Medicine, USA
12:45	Lunch
14:00	Poster Session & Discussion
14:30	Session 7: Nephronophthisis Chair: Friedhelm Hildebrandt, University of Michigan, USA Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease? Friedhelm Hildebrandt, University of Michigan, USA Signaling and subcellular localization of nephrocystins Gerd Walz, University Hospital Freiburg, Germany
	Emerging roles for cilia in the regulation of Wnt signaling Nicholas Katsanis, Johns Hopkins University, USA

Sunday, March 11, 2007
Time	Detailed Information
09:00	Session 8: Fibrosis / EMT Chair: Eric Neilson, Vanderbilt University School of Medicine, USA Secreted Mediators of BMP and TGF-beta Signaling in Renal Disease Gregory R Dressler, University of Michigan, USA Molecular mechanisms of epithelial-mesenchymal transition (EMT) in the kidney Eric Neilson, Vanderbilt University School of Medicine, USA Notch2, but not Notch1, is Essential for Proximal Fate Acquisition in the Mammalian Nephron Raphael Kopan, Washington University, USA
10:30	Coffee & Networking Break
11:00	Session 9: Familial focal glomerulosclerosis Chair: Michelle Winn, Duke University Medical Center, USA The role of alpha-actinin-4 in glomerular disease and function Martin Pollak, Brigham &Women's Hospital, Harvard Medical School, USA TRPC6 as a cause for Familial Focal and Segmental Glomerulosclerosis Michelle Winn, Duke University Medical Center, USA The cellular functions of polycystins Stefan Somlo, Yale University, USA
12:30	Concluding Remarks
12:45	Lunch