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Article
Nature Genetics  9, 80 - 85 (1995)
doi:10.1038/ng0195-80

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31−q33

J.B. Copeman1, F. Cucca1, C.M. Hearne1, R.J. Cornall1, P.W. Reed1, K.S. Rønningen2, D.E. Undlien2, L. Nisticò3, R. Buzzetti3, R. Tosi4, F. Pociot5, J. Nerup5, F. Cornélis6, A.H. Barnett7, S.C. Bain7 & J.A. Todd1

  1Nuffield Department of Surgery, The Wellcome Trust Centre for Human Genetics, University of Oxford, Windmill Road, Oxford OX3 7BN, UK

  2Institute of Transplantation Immunology, National Hospital, 0027 Oslo, Norway

  3Istituto Clinica Medica II, Università di Roma La Sapienza, Rome, Italy

  4Istituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche, Rome, Italy

  5Steno Diabetes Center, DK-2820 Gentofte, Denmark

  6INSERM U. 358, Hôspital St Louis, Bâtiment INSERM, 12 rue de la Grange aux Belles, 75010 Paris, France

  7Department of Medicine/Diabetes/Endocrinology, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK

 Correspondence should be addressed to J.A.T.

The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage disequilibrium at 21 microsatellite marker loci, using 348 affected sibpair families and 107 simplex families. The microsatellite D2S152 was linked to, and associated with, disease in families from three different populations. Our evidence localizes a new diabetes susceptibility gene, IDDM7, to within two centiMorgans of D2S152. This places it in a region of chromosome 2q that shows conserved synteny with the region of mouse chromosome 1 containing the murine type 1 diabetes gene, Idd5. These results demonstrate the utility of polymorphic microsatellites for linkage disequilibrium mapping of genes for complex diseases.

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EISSN: 1546-1718
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