Nature Genetics
7, 246 - 339 (1994)
doi:10.1038/ng0694supp-246
The 1993−94 Généthon human genetic linkage mapGabor Gyapay1, 2, Jean Morissette1, 3, Alain Vignal1, Colette Dib1, Cécile Fizames1, Philippe Millasseau1, 2, Sophie Marc1, Giorgio Bernardi4, Mark Lathrop5
& Jean Weissenbach1, 6
1Généthon, 1 rue de l'Internationale, 91000 Evry, France
2Centre d'Etudes du Polymorphismne Humain, 27 rue Juliette Dodu, 75010 Paris, France
3Réseau de Médecine Génétique, Centre Hospitalier de I'Université Laval, Québec, Canada
4Laboratoire de Génétique Moléculaire, Institut Jacques Monod, 2 place Jussieu, 75005 Paris, France
5INSERM U 358, 27 rue Juliette Dodu, 75010 Paris, France
6Unité de Génétique Moléculaire Humaine, CNRS URA 1445, Institut Pasteur, 75724 Paris Cédex, France In 1992, we described a second-generation genetic linkage map of the human genome. Using 1,267 new microsatellite markers, we now present a new genetic linkage map containing a total of 2,066 (AC)n short tandem repeats, 60% of which show a heterozygosity of over 0.7. Statistical linkage analysis based on the genotyping of eight large CEPH families placed these markers in the 23 linkage groups. The map includes 1,266 intervals and spans a total distance of 3690 centiMorgans (cM). A total of 1,041 markers could be ordered with odds ratios greater than 1000:1. About 56% of this map is at a distance of 1 cM or less from one of its markers. REFERENCES
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