Nature Genetics
7, 220 - 245 (1994)
doi:10.1038/ng0694supp-220
A genetic map of the mouse with 4,006 simple sequence length polymorphismsWilliam F. Dietrich1, Joyce C. Miller1, Robert G. Steen1, Mark Merchant1, Deborah Damron1, Robert Nahf1, Alec Gross1, Diane C. Joyce1, Michael Wessel1, Robert D. Dredge1, Andre Marquis1, Lincoln D. Stein1, Nathan Goodman1, David C. Page1
& Eric S. Lander1
1Whitehead Institute/MIT Center for Genome Research, Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA We have constructed a genetic map of the mouse genome containing 4,006 simple sequence length polymorphims (SSLPs). The map provides an average spacing of 0.35 centiMorgans (cM) between markers, corresponding to about 750 kb. Approximately 90% of the genome lies within 1.1 cM of a marker and 99% lies within 2.2 cM. The markers have an average polymorphism rate of 50% in crosses between laboratory strains. The markers are distributed in a relatively uniform fashion across the genome, although some deviations from randomness can be detected. In particular, there is a significant underrepresentation of markers on the X chromosome. This map represents the two−thirds point toward our goal of developing a mouse genetic map containing 6,000 SSLPs.
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