Association between atopy and variants of the subunit of the high−affinity immunoglobulin E receptor

The −subunit of the high−affinity IgE receptor (FcRI−) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of FcRI−, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60 unrelated nuclear families with allergic asthmatic probands, Leu181 is identified in 10 (17%), is maternally inherited in each, and shows a strong association with atopy. Our data indicate that FcRI−, subject to maternal modification, may be the atopy−causing locus on chromosome 11q.

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