Nature Genetics
7, 54 - 58 (1994)
doi:10.1038/ng0594-54
Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strainsWade H. Berrettini1, Thomas N. Ferraro1, Robert C. Alexander1, Arthur M. Buchberg2
& Wolfgang H. Vogel3
1Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
2Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
3Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two−bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.
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