Nature Genetics
7, 103 - 107 (1994)
doi:10.1038/ng0594-103
Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17qMichael R. Stratton1, Deborah Ford1, Susan Neuhasen2, Sheila Seal1, Richard Wooster1, Lori S. Friedman3, Mary-Clarie King3, Valgar Egilsson4, Peter Devilee5, Ross McManus6, Peter A. Daly6, Elizabeth Smyth7, Bruce A.J. Ponder8, Julian Peto1, Lisa Cannon-Albright9, Douglas F. Easton1
& David E. Goldgar2
1Section of Molecular Carcinogenesis and CRC Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
2Genetic Epidemiology, Department of Medical Informatics, University of Utah, Salt Lake City, Utah 84108, USA
3Department of Molecular and Cell Biology and School of Public Health, University of California, Berkeley, California 94720, USA
4Laboratory of Cell Biology, University Hospital of Iceland, PO Box 1465, 121 Reykjavik, Iceland
5Department of Pathology, University of Leiden, Wassenaarseweg 62, 2333, AL Leiden, The Netherlands
6Department of Medicine, Trinity College Medical School St. James Hospital, Dublin 8, Ireland
7MRC Human Genetics Unit, Western General Hospital Crewe Rd, Edinburgh EH4 2XU, UK
8CRC Human Cancer Genetics Group, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
9Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA Breast cancer in men is about a hundredfold less common than in women and this has hindered research into its genetic basis. We have examined 22 families with at least one case of male breast cancer for linkage to the hereditary breast and ovarian cancer locus, BRCA1, on chromosome 17q. We found strong evidence against linkage to BRCA1 (lod score − 16.63) and the best estimate of the proportion of linked families was 0% (95% Cl 0−18%). Our results indicate that there is a gene(s) other than BRCA1 which predisposes to early−onset breast cancer in women and which confers a higher risk of male breast cancer. Identification of additional pedigrees that include cases of male breast cancer may therefore facilitate the mapping and isolation of this gene.
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