Nature Genetics
6, 391 - 393 (1994)
doi:10.1038/ng0494-391
Integrated human genome−wide maps constructed using the CEPH reference panelKenneth H. Buetow1, James L. Weber2, Susan Ludwigsen1, Titia Scherpbier-Heddema1, Geoffrey M. Duyk3, Val C. Sheffield4, Zhenyuan Wang2
& Jeffrey C. Murray4
1Division of Population Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
2Center for Medical Genetics, Marshfield Medical Research Foundation, Marshfield, Wisconsin 54449, USA
3Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School Boston, Massachusetts 02115, USA
4Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA Correspondence should be addressed to K.H.B. High resolution linkage maps have proven to be invaluable tools in genetic investigations. We have assembled a collection of genetic maps constructed from primary data collected from investigators performing genotyping using the Centre Etude Polymorphism Humain (CEPH) reference pedigree panel. These maps were constructed using a rigorous, semi−automated map construction algorithm that evaluates the integrity of the maps during construction. Two classes of maps were produced: a high confidence "skeletal" set composed of 544 PCR based markers, and a more highly annotated "framework" set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an additional 1,758 loci without statistically unique interval assignments.
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