Nature Genetics
6, 363 - 368 (1994)
doi:10.1038/ng0494-363
A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18Yoshinobu Asada1, 2, Don S. Varnum1, Wayne N. Frankel1
& Joseph H. Nadeau1
1Jackson Laboratory, Bar Harbor, Maine 04609, USA
2Department of Pedodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271, Japan Correspondence should be addressed to J.H.N. Little is known about inherited susceptibility to spontaneous germ cells tumours in humans or other species. The Ter mutation in laboratory mice is novel in that it acts codominantly to reduce germ cell numbers on many inbred strain backgrounds and to enhance dramatically inherited predisposition to spontaneous testicular teratocarcinomas in strain 129 inbred mice. We have adopted a PCR−based, DMA pooling method for mice with 'extreme' phenotypes (small testes versus normal−sized testes) to identify a candidate linkage to the Ter locus. Two independent mapping approaches confirmed this evidence for Ter linkage near D18Mit62 on mouse chromosome 18, and suggest a possible human homologue on chromosome 5q.
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