Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development

1. Hill, R.E. et al. A new family of mouse homeo box-containing genes: molecular structure chromosomal location & developmental expression of Hox-7.1. Genes Dev. 3, 26−37 (1989). | PubMed  | ISI | ChemPort |
2. Robert, B., Sassoon, D., Jacq, B., Gehring, W. & Buckingham, M. >Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J. 8, 91−100 (1989). | PubMed  | ISI | ChemPort |
3. Gehring, W.J. The homeobox: Structural and evolutionary aspects, in Molecular Approaches toDevelopmental Biology (eds Firtel, R.A. & Davidson, E.H.) 115−129 (Liss, New York, 1987). | ChemPort |
4. Holland, P.W.H. Cloning and evolutionary analysis of msh like homeobox genes from mouse, zebrafish and ascidian. Gene 98, 253−257 (1991). | Article | PubMed  | ISI | ChemPort |
5. Monaghan, A.P. et al. The Msh-like homeobox genes define domains in the developing vertebrate eye. Development 112,1053−1061 (1991). | PubMed  | ISI | ChemPort |
6. Bell, J.R. et al. Genomic structure, chromosomal location, and evolution of the mouse Hox-8 gene. Genomics 16, 123−131 and 17, 800 (1993). | Article | PubMed  | ISI | ChemPort |
7. Ivens, A. et al. The human homeobox gene Hox7 maps chromosome 4p16.1 and may be implicated in Wolf-Hirschhorn syndrome. Human Genet. 84, 473−476 (1990). | ISI | ChemPort |
8. Hewitt, J.E., Clark, L.N., Ivens, A. & Williamson, R. Structure and sequence of the human homeobox gene Hox7. Genomics 11, 670−678 (1991). | PubMed  | ISI | ChemPort |
9. Jabs, E.W. et al. A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell 75, 443−450 (1993). | Article | PubMed  | ISI | ChemPort |
10. MacKenzie, A., Leeming, G.L., Jowett, A.K., Ferguson, M.W.J. & Sharpe, P.T. The homeobox gene Hox7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro. Development 111, 269−285 (1991). | PubMed  | ISI | ChemPort |
11. MacKenzie, A., Ferguson, M.W.J. & Sharpe, P.T. Hox-7 expression during murine craniofacial development. Development 113, 601−611 (1991). | PubMed  | ISI | ChemPort |
12. MacKenzie, A., Ferguson, M.W.J. & Sharpe, P.T. Expression patterns of the homeobox gene Hox 8 in the mouse embryo suggest a role in specifying tooth initiation and shape. Development 115, 403−420 (1992). | PubMed  | ISI | ChemPort |
13. Suzuki, H.R., Padanilam, B.J., Vitale, E., Ramirez, F. & Solursh, M. Repeating developmental expression of G-Hox7, a novel homeobox-containing gene in the chicken. Dev. Biol. 148, 375−388 (1991). | PubMed  | ISI | ChemPort |
14. Lyons, G.E., Houzelstein, D., Sassoon, D., Robert, B. & Buckingham, M. Multiple sites of Hox-7 expression during mouse embryogenesis: comparison with retinoic acid receptor mRNA localization. Molec. repro. Dev. 32, 303−314(1992). | ISI | ChemPort |
15. Chan-Thomas, P.S., Thompson, R.P., Robert, B., Yacoub, M.H. & Barton, P.J.R. Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in chick. Develop. Dyn. 197, 203−216 (1993). | ChemPort |
16. Robert, B., Lyons, G., Simandl, B.K., Kuroiwa, A. & Buckingham, M. The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds. Genes Dev. 5, 2363−2374 (1991). | PubMed  | ISI | ChemPort |
17. Davidson, D.R., Crawley, A., Hill, R.E. & Tickle, C. Position dependent expression of two related homeobox genes in developing vertebrate limbs. Nature 352, 429−431 (1991). | Article | PubMed  | ISI | ChemPort |
18. Coelho, C.N.D., Krabbenhoft, K.M., Upholt, W.B., Fallon, J.F. & Kosher, R.A. Altered expression of the chicken homeobox-containing gene GHox-7 and GHox-8 in the limb buds of limbless mutant chick embryos. Development 113, 1487−1493 (1991). | PubMed  | ISI | ChemPort |
19. Coelho, C.N.D., Upholt, W.B. & Kosher, R.A. Role of the chicken homeobox-containing genes GHox-4.6 and GHox-8 in the specification of positional identities during the development of normal and polydactylous chick limb buds. Development 115, 629−637 (1992). | PubMed  | ISI | ChemPort |
20. Ros, M.A. et al. Apical ridge dependent and independent mesodermal domains of GHox-7 and GHox-8 expression in chick limb buds. Development 116, 811−818 (1992). | PubMed  | ISI | ChemPort |
21. Brown, J.M. et al. Experimental analysis of the control of expression of the homeobox-gene Msx-1 in the developing limb and face. Development 119, 41−48 (1993). | PubMed  | ISI | ChemPort |
22. Takahashi, Y., Bontoux, M. & Le Douarin, N.M. Epithelio-mesenchymal interactions are critical for Quox 7 expression and membrane bone differentiation in the neural crest derived mandibular mesenchyme. EMBOJ. 10, 2387−2393(1991). | ChemPort |
23. Jowett, A.K., Vainio, S., Ferguson, M.W.J., Sharpe, P.T. & Thesleff, I. Epithelial-mesenchymal interactions are required for msx1 and msx2 gene expression in the developing murine molar tooth. Development 117, 461−470(1993). | PubMed  | ISI | ChemPort |
24. Takahashi, Y., Monsoro-Burg, A.-H., Bontoux, M. & Le Douarin, N.M.A role for Quox-8 in the establishment of the dorsoventral pattern during vertebrate development. Proc. natn. Acad. Sci. U.S.A. 89, 10237−10241 (1992). | ChemPort |
25. Davidson, D.R. & Hill, R.E. Msh-like genes: a family of homeobox genes with wide ranging expression during vertebrate development. Sem. Dev. Biol. 2, 405−412 (1991).
26. Muneoka, K. & Sasoon, D. Molecular aspects of regeneration in developing vertebrate limbs. Dev. Biol. 152, 37−49 (1992). | PubMed  | ISI | ChemPort |
27. Izpisúa-Belmonte, J.-C. & Duboule, D. Homeobox genes and pattern formation in the vertebrate limb. Dev. Biol. 152, 26−36 (1992). | PubMed  | ISI |
28. Davidson, E.H. Later embryogenesis: regulatory circuitry in morphogenetic fields. Development 118, 665−690 (1993). | PubMed  | ISI | ChemPort |
29. Robert, B. et al. Induction phenomena in vertebrate limb formation and expression of homeobox genes. Ann. Génétique 36, 39−45 (1993). | ChemPort |
30. Gorlin, R.J., Cohen, M.M.Jr., & Levin, L.S. Syndromes of the Head and Neck. Oxford Monograph on Medical genetics No. 19, Third edition. 693−714 (Oxford University Press, Oxford, England, 1990).
31. Ranta, R.A review of tooth formation in children with cleft lip/palate. A. J. Orthod. Dentofac. Orthop. 90, 11−18 (1986). | ISI | ChemPort |
32. Randall, P., Krogman, W.M. & Jahina, S., Robin and the syndrome that bears his name. Cleft Palate J. 2, 237−246 (1965).
33. McKusick, V.A. Mendelian Inheritance in Man. 8th edn 1138−1139 (Johns Hopkins University Press, Baltimore 1988).
34. Couly, G.andLe Douarin, N.M. The fate map of the cephalic neural primordium at the presomitic to the 3-somite stage in the avian embryo. Development Supp. 103, 101−113 (1988).
35. Couly, G.F., Coltey, P.M. & Le Douarin, N.M. The triple origin of skull in higher vertebrates: a study in quail-chick chimeras. Development 117, 409−429 (1993). | PubMed  | ISI | ChemPort |
36. Noden, D.M. Interactions and fates of avian craniofacial mesenchyme. Development Supp. 103, 121−140 (1988).
37. Lumsden, A.G.S. Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ. Development Supp. 103, 155−169 (1988).
38. Johnston, M.C. The neural crest in abnormalities of the face and brain. Birth Defects: Original Article Series, Vol. Xl(7), 118 (The National March of Dimes Foundation, 1975).
39. Sulik, K.K., Cook, C.S. & Webster, W.S. Teratogenesis and craniofacial malformations: relationships to cell death. Development Supp. 103, 213−232 (1988). | ChemPort |
40. Palmer, R.M. & Lumsden, A.G.S. Development of periodontal ligament and alveolar bone in homografted recombinations of enamel organs and papillary, pulpal and follicular mesenchyme in the mouse. Arch. Oral Biol. 32, 281−289 (1987). | Article | PubMed  | ISI | ChemPort |
41. Vainio, S., Karavanova, I., Jowett, A. & Thesleff, I. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 75, 45−58 (1993). | Article | PubMed  | ISI | ChemPort |
42. Coelho, C.N.D. et al. Expression of the chicken homeobox-containing gene GHox-8 during embryonic chick limb development. Mech. Dev. 34, 143−154 (1991). | Article | PubMed  | ISI | ChemPort |
43. Coelho, C.N.D., Sumoy, L.,Kosher, R.A. & Upholt, W.B., GHox-7: A chicken homeobox-containing gene expressed in a fashion consistent with a role in patterning events during embryonic chick limb development. Differentiation 49, 85−92 (1992). | PubMed  | ISI | ChemPort |
44. Ferguson, M. Palate development. Development Supp. 103, 41−60 (1988).
45. Fitch, N. Development of cleft palate in mice homozygous for the shorthead mutation. J. Morphot. 109, 151−157 (1961). | ChemPort |
46. Seegmiller, R.E. & Fraser, F.C. Mandibular growth retardation as a cause of cleft palate in mice homozygous for the chondrodysplasia gene. J. Embryol. exp. Morph. 38, 227−238 (1977). | PubMed  | ISI | ChemPort |
47. Juriloff, D.M. & Harris, M.J. Abnormal facial development in the mouse mutant first arch. J. Cranio. Gen. devl. Biol. 3, 317−337 (1983). | ChemPort |
48. Culiat, C.T. et al. Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the ₃ subunit of the type A-aminobutyric acid receptor. Proc. natn. Acad. Sci. U.S.A. 90, 5105−5109(1993). | ChemPort |
49. Nakatsu, Y. et al. A cluster of three GABA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature 364, 448−450 (1993). | Article | PubMed  | ISI | ChemPort |
50. Gendron-Maguire, M. et al. Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest. Cell 75, 1317−1331 (1993). | PubMed  | ChemPort |
51. Rijli, F.M. et al. A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a homeotic selector gene. Cell 75, 1333−1349 (1993). | PubMed  | ISI | ChemPort |
52. Farrall, M. & Holder, S. Familal recurrence-pattern analysis of cleft lip with or without cleft palate. Am. J. hum. Gen. 50, 270−277 (1992). | ISI | ChemPort |
53. Marazita, M.L., Hu, D-N, Spence, M.A.,Liu, Y-E.,Melnick, M. Cleft lip with or without cleft palate in Shanghai, China: evidence for an autosomal major locus. Am. J. hum. Gen. 51, 648−653 (1992). | ISI | ChemPort |
54. Kurnit, D.M., Layton, W.M. & Matthysse, S., Genetics, chance, and morphogenesis. Am. J. hum. Gen. 41, 979−995 (1987). | ISI | ChemPort |
55. Li, E., Bestor, T. & Jaenisch, R.argeted mutation of the DNA methyl transferase gene results in embryonic lethality. Cell 69, 915−926 (1992). | Article | PubMed  | ISI | ChemPort |
56. Zijlstra, M., Li, E., Sajjadi, F., Subramani, S. & Jaensich, R. Germ line transmission of adisrupted 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342, 435−438 (1989). | Article | PubMed  | ISI | ChemPort |
57. Robertson, E.J. Embryo-derived stem cell lines in Teratocarcinomas and embryonic stem cells a practical approach (ed. Roberston. E.J.)71−112(IRL press, Oxford, 1987).
58. Thomas, K. & Capecchi, M. Site directed mutagenesis by gene targeting in mouse embryo derived stem cells. Cell 51, 503−512 (1987). | Article | PubMed  | ISI | ChemPort |
59. Bradley, A. Production and analysis of chimaeric mice. in Teratocarcinomas and embryonic stem cells, a practical approach (ed. Robertson, E.J.) 113−151 (IRL Press, Oxford, 1987).
60. Laird, P.W. et al. Simplified mammalian DNA isolation procedure. Nuc. Acid Res. 19, 4293 (1991). | ISI | ChemPort |
61. McLeod, M.J. Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. Teratology 22, 299−301 (1980). | PubMed  | ISI | ChemPort |

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