Nature Genetics
6, 106 - 110 (1994)
doi:10.1038/ng0194-106
Epidermolytic palmoplantar keratoderma cosegregates with a keratin 9 mutation in a pedigree with breast and ovarian cancerD. Torchard1, C. Blanchet-Bardon2, O. Serova3, L. Langbein4, S. Narod5, N. Janin6, A.F. Goguel7, A. Bernheim7, W.W. Franke4, G.M. Lenoir3
& J. Feunteun1, 8
1Laboratoire d'Oncologie Moléculaire, CNRS URA 1158
2Clinique des maladies cutanées (Pr. L. Dubertret), Hopital Saint-Louis, 1, Avenue Claude Vellefaux, 75010, Paris, France
3International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France
4Deutsches Krebsforschungzentrum, Heidelberg, Germany
5Centre for Human Genetics and Departments of Medicine and Oncology, Mc Gill University, Montréal Canada
6Departement de Médecine, Institut Gustave Roussy, 94805 Villejuif Cedex, France
7Laboratoire de Cytogénétique et Génétique Oncologique, Institut Gustave Roussy 94805 Villejuif Cedex, France
8Correspondence should be addressed to J.F. Epidermolytic palmoplantar keratosis (EPPK) cosegregates with breast and ovarian cancers in a large French pedigree, raising the possibility that a single genetic mutation might cause these conditions and offering a potential lead to the identification of a hereditary breast/ovarian cancer gene. We have performed linkage analysis and show that the EPPK locus lies on the long arm of chromosome 17 near the type I keratin gene cluster and the proposed breast cancer gene (BRCA1). The type I keratin 9 gene has been partially sequenced in four affected individuals. A single base mutation within the rod domain of the protein cosegregates with EPPK in all affected individuals tested. Although inheritance of this mutation is likely responsible for EPPK, it is unlikely to be the cause of the breast and ovarian cancer.
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