Nature Genetics
5, 95 - 100 (1993)
doi:10.1038/ng0993-95
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid  protein precursorWilma Wasco1, Sarada Gurubhagavatula1, Marc d. Paradis1, Donna M. Romano1, Sangram S. Sisodia2, Bradley T. Hyman3, Rachael L. Neve4
& Rudolph E. Tanzi1
1Laboratory of Genetics and Aging, Neuroscience Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
2Department of Pathology and the Neuropathology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2181, USA
3Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
4Mailman Research Center, McLean Hospital, Belmont, Massachusetts 02178, USA Correspondence should be addressed to W.W. Familial Alzheimer's disease (FAD) is a genetically heterogeneous disorder that includes a rare early−onset form linked to mutations in the amyloid b protein precursor (APP) gene. Clues to the function of APP derive from the recent finding that it is a member of a highly conserved protein family that includes the mammalian amyloid recursor−like protein (APLP1) gene which maps to the same general region of human chromosome 19 linked to late−onset FAD. Here we report the isolation of the human APLP2 gene. We show that APLP2 is a close relative of APP and exhibits a very similar pattern of expression in the brain and throughout the body. Like APP, APLP2 contains a cytoplasmic domain predicted to couple with the GTP−binding protein Go indicating that it may be an additional cell surface activator of this G protein.
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