Nature Genetics
5, 66 - 70 (1993)
doi:10.1038/ng0993-66
LAZ3, a novel zinc−finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomasJean-Pierre Kerckaert1, Clotilde Deweindt1, Hervé Tilly2, Sabine Quief1, Gérard Lecocq1
& Christian Bastard3
1Unité 124 INSERM, Institut de Recherches sur le Cancer de Lille, Place de Verdun, 59045 Lille cedex, France
2Centre Henri Becquerel, rue d'Amiens, 76038 Rouen, France
3Departement de Cytogénétique, Centre Régional de transfusion sanguine, 609 chemin de la Bretèque, BP 58, 76232 Bois-Guillaume Cedex, France Correspondence should be addressed to J.P.K. We have shown previously that chromosomal translocations involving chromosome 3q27 and immunoglobulin gene regions are the third most common specific translocations in non−Hodgkin's lymphoma (NHL). We now report the isolation of a gene that is disrupted in two cases by t(3;14) and t(3;4) translocations. The gene (LAZ3) encodes a 79 kDa protein containing six zinc−finger motifs and sharing amino−terminal homology with several transcription factors including the Drosophila tramtrack and Broad−complex genes, both of which are developmental transcription regulators. LAZ3 is transcribed as a 3.8 kb message predominantly in normal adult skeletal muscle and in several NHL carrying 3q27 chromosomal defects. We suggest that it may act as a transcription regulator and play an important role in lymphomagenesis.
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