Nature Genetics
5, 40 - 45 (1993)
doi:10.1038/ng0993-40
A gene for familial hemiplegic migraine maps to chromosome 19Anne Joutel1, 2, Marie-Germaine Bousser2, Valérie Biousse2, Pierre Labauge3, Hugues Chabriat1, 2, Argentino Nibbio1, Jacqueline Maciazek1, Bénédicte Meyer1, Marie-Anne Bach1, Jean Weissenbach4, 5, G. Mark Lathrop6
& Elisabeth Tournier-Lasserve1
1Laboratoire de Pathologie de l'Immunité, Faculté de Médecine Necker, Enfants-Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
2Service de Neurologie, Hopital St Antoine, Paris, France
3Clinique Neurologique du C.H. et U. Montpellier-Nîmes, France
4Unité de Génétique Moléculaire Humaine (CNRS URA 1445) Institut Pasteur, Paris, France
5Généthon, 91000 Evry, France
6Unité INSERM U358, CEPH, Paris, France Correspondence should be addressed to E.T.-L. Familial hemiplegic migraine is an autosomal dominant disorder of unknown pathogenesis in which the migrainous attacks are marked by the occurrence of a transient hemiplegia during the aura. While investigating CADASIL, mapped previously to chromosome 19, we observed that some patients had recurrent attacks of migraine with aura. Although the clinical and neuroimaging features of familial hemiplegic migraine differ markedly from CADASIL, we hypothesized that the same gene could be involved in the pathogenesis of both conditions. We chose two large pedigrees for linkage analysis of familial hemiplegic migraine. A maximum lod score > 8 was found with two markers that are also strongly linked to CADASIL Multilocus linkage analysis suggested that the loci responsible for the two diseases reside within an interval of about 30 cM on chromosome 19.
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