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Genetic insights into mammalian heart regeneration

Nature Genetics volume 49, pages 1292–1293 (2017)Cite this article

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Genetic and functional analyses of 120 mouse strains have identified a heart regeneration candidate gene that modulates the contractile sarcomeric apparatus. This gene, Tnni3k, controls the frequency of the mononuclear, diploid cardiomyocyte population, which affects cardiomyocyte proliferative potential after injury.

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Figure 1: Genetic influence on heart regeneration.

Debbie Maizels/Springer Nature

References

  1. Porrello, E.R. et al. Science 331, 1078–1080 (2011).

    Article  CAS  Google Scholar 

  2. Mollova, M. et al. Proc. Natl. Acad. Sci. USA 110, 1446–1451 (2013).

    Article  CAS  Google Scholar 

  3. Senyo, S.E. et al. Nature 493, 433–436 (2013).

    Article  CAS  Google Scholar 

  4. Bergmann, O. et al. Science 324, 98–102 (2009).

    Article  CAS  Google Scholar 

  5. Bergmann, O. et al. Cell 161, 1566–1575 (2015).

    Article  CAS  Google Scholar 

  6. Patterson, M. et al. Nat. Genet. 49, 1346–1353 (2017).

    Article  CAS  Google Scholar 

  7. Vagnozzi, R.J. et al. Sci. Transl. Med. 5, 207ra141 (2013).

    Article  Google Scholar 

  8. Wheeler, F.C. et al. PLoS Genet. 5, e1000647 (2009).

    Article  Google Scholar 

  9. Soonpaa, M.H., Kim, K.K., Pajak, L., Franklin, M. & Field, L.J. Am. J. Physiol. 271, H2183–H2189 (1996).

    CAS  PubMed  Google Scholar 

  10. Ikenishi, A. et al. Dev. Growth Differ. 54, 731–738 (2012).

    Article  CAS  Google Scholar 

  11. Eschenhagen, T. et al. Circulation http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029343 (2017).

  12. Ahuja, P., Sdek, P. & MacLellan, W.R. Physiol. Rev. 87, 521–544 (2007).

    Article  CAS  Google Scholar 

  13. Anatskaya, O.V. & Vinogradov, A.E. Genomics 89, 70–80 (2007).

    Article  CAS  Google Scholar 

  14. Yuan, X. & Braun, T. Circ. Res. 121, 293–309 (2017).

    Article  CAS  Google Scholar 

  15. Theis, J.L. et al. Hum. Mol. Genet. 23, 5793–5804 (2014).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. the Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA

    Ana Vujic, Vinícius Bassaneze & Richard T Lee

Authors
  1. Ana Vujic
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  2. Vinícius Bassaneze
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  3. Richard T Lee
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Correspondence to Richard T Lee.

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The authors declare no competing financial interests.

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Vujic, A., Bassaneze, V. & Lee, R. Genetic insights into mammalian heart regeneration. Nat Genet 49, 1292–1293 (2017). https://doi.org/10.1038/ng.3942

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