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Transposase-driven rearrangements in human tumors

Nature Genetics volume 49, pages 975–977 (2017)Cite this article

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A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cancer gene identification.

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Figure 1: PGBD5 promotes chromosomal rearrangements in rhabdoid tumors.

Debbie Maizels/Springer Nature

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Authors and Affiliations

  1. Cleveland Clinic, Stem Cell Biology and Regenerative Medicine, Cleveland, Ohio, USA

    Stephen C Mack

  2. Department of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada

    Hiromichi Suzuki & Michael D Taylor

Authors
  1. Stephen C Mack
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  2. Hiromichi Suzuki
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  3. Michael D Taylor
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Corresponding author

Correspondence to Michael D Taylor.

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The authors declare no competing financial interests.

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Mack, S., Suzuki, H. & Taylor, M. Transposase-driven rearrangements in human tumors. Nat Genet 49, 975–977 (2017). https://doi.org/10.1038/ng.3908

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