A new study uses a Hi-C technique to demonstrate that condensin has a major role in remodeling interphase chromatin into mitotic chromosomes. This study provides insight into the mechanism whereby a centimeters-long DNA molecule is folded into a micrometers-long rod-shaped chromosome.
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References
Flemming, W. Zellsubstanz, Kern und Zelltheilung (F.C.W. Vogel, 1882).
Hirano, T. Cell 164, 847–857 (2016).
Kschonsak, M. & Haering, C.H. BioEssays 37, 755–766 (2015).
Shintomi, K. et al. Science 356, 1284–1287 (2017).
Kakui, Y., Rabinowitz, A., Barry, D.J. & Uhlmann, F. Nat. Genet. 49, 1553–1557 (2017).
Umesono, K., Hiraoka, Y., Toda, T. & Yanagida, M. Curr. Genet. 7, 123–128 (1983).
Saka, Y. et al. EMBO J. 13, 4938–4952 (1994).
Naumova, N. et al. Science 342, 948–953 (2013).
Lazar-Stefanita, L. et al. EMBO J. http://dx.doi.org/10.15252/embj.201797342 (2017).
Shalbetter, S.A. et al. Nat. Cell Biol. 19, 1071–1080 (2017).
Lavoie, B.D., Hogan, E. & Koshland, D. J. Cell Biol. 156, 805–815 (2002).
D'Amours, D., Stegmeier, F. & Amon, A. Cell 117, 455–469 (2004).
Sullivan, M., Higuchi, T., Katis, V.L. & Uhlmann, F. Cell 117, 471–482 (2004).
Gibcus, J.H. et al. Preprint at bioRxiv http://dx.doi.org/10.1101/174649 (2017).
Nagano, T. et al. Nature 547, 61–67 (2017).
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Hirano, T. Capturing condensin in chromosomes. Nat Genet 49, 1419–1420 (2017). https://doi.org/10.1038/ng.3962
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DOI: https://doi.org/10.1038/ng.3962
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