Our understanding of how DNA copy number changes contribute to disease, including cancer, has to a large degree been focused on the changes in gene dosage that they generate and has neglected the effects of the DNA rearrangements that lead to their formation. A new study reports an innovative analytical framework for copy number alterations that are oncogenic primarily owing to the genomic rearrangements that underlie them.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Identification and utilization of copy number information for correcting Hi-C contact map of cancer cell lines
BMC Bioinformatics Open Access 07 November 2020
-
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Nature Genetics Open Access 05 February 2020
-
A systematic evaluation of copy number alterations detection methods on real SNP array and deep sequencing data
BMC Bioinformatics Open Access 24 December 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zack, T.I. et al. Nat. Genet. 45, 1134–1140 (2013).
Weischenfeldt, J. et al. Nat. Genet. 49, 65–74 (2017).
Wong, A.J. et al. Proc. Natl. Acad. Sci. USA 89, 2965–2969 (1992).
Ong, C.-T. & Corces, V.G. Nat. Rev. Genet. 12, 283–293 (2011).
Hnisz, D., Day, D.S. & Young, R.A. Cell 167, 1188–1200 (2016).
Northcott, P.A. et al. Nature 511, 428–434 (2014).
Battey, J. et al. Cell 34, 779–787 (1983).
Bandopadhayay, P. et al. Nat. Genet. 48, 273–282 (2016).
Tomlins, S.A. et al. Science 310, 644–648 (2005).
Gröschel, S. et al. Cell 157, 369–381 (2014).
Zhang, X. et al. Nat. Genet. 48, 176–182 (2016).
Hnisz, D. et al. Science 351, 1454–1458 (2016).
Cancer Genome Atlas Network. Nature 487, 330–337 (2012).
Stephens, P.J. et al. Cell 144, 27–40 (2011).
Baca, S.C. et al. Cell 153, 666–677 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
R.B. receives research support from and is a consultant for Novartis. M.M. receives research support from Bayer and is a founding advisor of Foundation Medicine, for which he was previously a consultant and in which he previously held equity.
Rights and permissions
About this article
Cite this article
Beroukhim, R., Zhang, X. & Meyerson, M. Copy number alterations unmasked as enhancer hijackers. Nat Genet 49, 5–6 (2017). https://doi.org/10.1038/ng.3754
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3754
This article is cited by
-
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation
Nature Reviews Molecular Cell Biology (2024)
-
Transcriptome sequencing identifies novel EVX fusions involved in transcriptional activation of HOX family genes in pediatric immature T-cell acute lymphoblastic leukemia: two cases reports and a literature review
International Journal of Hematology (2023)
-
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma
Nature Cancer (2022)
-
Identification and utilization of copy number information for correcting Hi-C contact map of cancer cell lines
BMC Bioinformatics (2020)
-
Single-cell analysis of structural variations and complex rearrangements with tri-channel processing
Nature Biotechnology (2020)
