Abstract
Crop breeding is being revolutionized by rapid progress in DNA sequencing and targeted alteration of DNA sequences by genome editing. Here we propose a regulatory framework for precision breeding with 'genome-edited crops' (GECs) so that society can fully benefit from the latest advances in plant genetics and genomics.
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References
Arabidopsis Genome Initiative. Nature 408, 796–815 (2000).
Goff, S.A. et al. Science 296, 92–100 (2002).
Yu, J. et al. Science 296, 79–92 (2002).
Huang, S. et al. Nat. Genet. 41, 1275–1281 (2009).
Berlin, K. et al. Nat. Biotechnol. 33, 623–630 (2015).
Lin, T. et al. Nat. Genet. 46, 1220–1226 (2014).
Qi, J. et al. Nat. Genet. 45, 1510–1515 (2013).
Huang, X. et al. Nature 490, 497–501 (2012).
Zhou, Z. et al. Nat. Biotechnol. 33, 408–414 (2015).
Araus, J.L. & Cairns, J.E. Trends Plant Sci. 19, 52–61 (2014).
Zetsche, B. et al. Cell 163, 759–771 (2015).
Sternberg, S.H. & Doudna, J.A. Mol. Cell 58, 568–574 (2015).
Baltes, N.J. & Voytas, D.F. Trends Biotechnol. 33, 120–131 (2015).
Woo, J.W. et al. Nat. Biotechnol. 33, 1162–1164 (2015).
Shukla, V.K. et al. Nature 459, 437–441 (2009).
Li, T., Liu, B., Spalding, M.H., Weeks, D.P. & Yang, B. Nat. Biotechnol. 30, 390–392 (2012).
Wang, Y. et al. Nat. Biotechnol. 32, 947–951 (2014).
Schönbrunn, E. et al. Proc. Natl. Acad. Sci. USA 98, 1376–1380 (2001).
Wang, M. et al. PLoS One 10, e0122755 (2015).
Townsend, J.A. et al. Nature 459, 442–445 (2009).
Park, S.J. et al. Nat. Genet. 46, 1337–1342 (2014).
Xie, K., Minkenberg, B. & Yang, Y. Proc. Natl. Acad. Sci. USA 112, 3570–3575 (2015).
European Food Safety Authority. EFSA J. 10, 2561–2593 (2012).
Obama, B. Fed. Regist. 76, 3821–3823 (2011).
Ledford, H. Nature 500, 389–390 (2013).
Acknowledgements
We thank our colleagues D. Baulcombe, J. Dangl, J. Jones, O. Leyser, X. Meng, X. Yang and B. Hu for discussion. The authors have no direct competing financial interests. D.W. is a co-founder and shareholder of Computomics, which provides bioinformatics services primarily to the breeding industry. D.W. has been an adviser to Bayer Crop Sciences in the past. R.N.B. is on the Board of Directors for Symbiota Co. and Performance Plants, Inc. and is Chief Scientific Officer (CSO) for Kultevat Co. S.H. is supported by funding from the Ministry of Sciences and Technologies (the 973 Program; 2012CB113900) and the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences (CAAS-ASTIP-2015-AGISCAAS). All of the funding to D.W. comes from governmental or nonprofit sources (Max Planck Society, European Research Council, German Research Council DFG, and the Gordon and Betty Moore Foundation/2Blades Foundation).
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Supplementary information
Supplementary Table 1
Forty-seven important crop species for which whole-genome sequences are available. (PDF 146 kb)
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Huang, S., Weigel, D., Beachy, R. et al. A proposed regulatory framework for genome-edited crops. Nat Genet 48, 109–111 (2016). https://doi.org/10.1038/ng.3484
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DOI: https://doi.org/10.1038/ng.3484
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