Stabilization of p53 protein is a key step in the cellular response to DNA damage. A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA damage.
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References
Menendez, D., Inga, A. & Resnick, M.A. Nat. Rev. Cancer 9, 724–737 (2009).
Grossi, E., Sánchez, Y. & Huarte, M. Biochim. Biophys. Acta 1859, 200–208 (2016).
Djebali, S. et al. Nature 489, 101–108 (2012).
Guttman, M. et al. Nature 458, 223–227 (2009).
Schmitt, A.M. et al. Nat. Genet. 48, 1370–1376 (2016).
Ulitsky, I. Nat. Rev. Genet. 17, 601–614 (2016).
Ulitsky, I. & Bartel, D.P. Cell 154, 26–46 (2013).
Brown, J.P., Wei, W. & Sedivy, J.M. Science 277, 831–834 (1997).
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Huarte, M. p53 partners with RNA in the DNA damage response. Nat Genet 48, 1298–1299 (2016). https://doi.org/10.1038/ng.3702
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DOI: https://doi.org/10.1038/ng.3702
