Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The genomic landscape of adult T cell leukemia/lymphoma

Adult T cell leukemia/lymphoma (ATL) is a neoplasm linked to human T-lymphotropic virus type-1 (HTLV-1) infection and is refractory to current combination chemotherapy. A large genomic and transcriptomic study of ATL now provides detailed insight into the molecular lesions implicated in the development of this T cell malignancy.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Pathways altered in ATL.

References

  1. Matsuoka, M. & Jeang, K.T. Oncogene 30, 1379–1389 (2011).

    Article  CAS  Google Scholar 

  2. Ishitsuka, K. & Tamura, K. Lancet Oncol. 15, e517–e526 (2014).

    Article  CAS  Google Scholar 

  3. Matsuoka, M. & Yasunaga, J. Curr. Opin. Virol. 3, 684–691 (2013).

    Article  CAS  Google Scholar 

  4. Kataoka, K. et al. Nat. Genet. 47, 1304–1315 (2015).

    Article  CAS  Google Scholar 

  5. Nakagawa, M. et al. J. Exp. Med. 211, 2497–2505 (2014).

    Article  CAS  Google Scholar 

  6. Goon, P.K. et al. J. Infect. Dis. 189, 2294–2298 (2004).

    Article  Google Scholar 

  7. De Keersmaecker, K. et al. Nat. Genet. 45, 186–190 (2013).

    Article  CAS  Google Scholar 

  8. Palomero, T. et al. Nat. Genet. 46, 166–170 (2014).

    Article  CAS  Google Scholar 

  9. Young, R.M. et al. Semin. Hematol. 52, 77–85 (2015).

    Article  CAS  Google Scholar 

  10. Ysebaert, L. & Morschhauser, F. Expert Opin. Investig. Drugs 20, 1167–1174 (2011).

    Article  CAS  Google Scholar 

  11. El-Gamal, D. et al. Blood 124, 1481–1491 (2014).

    Article  CAS  Google Scholar 

  12. Ogura, M. et al. J. Clin. Oncol. 32, 1157–1163 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jan Cools.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vicente, C., Cools, J. The genomic landscape of adult T cell leukemia/lymphoma. Nat Genet 47, 1226–1227 (2015). https://doi.org/10.1038/ng.3428

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3428

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research