To establish and maintain chronic infections, many pathogens adapt in response to selective pressures within the host, leaving unique genetic signatures. A new study uses whole-genome and population sequencing approaches to identify evidence of adaptive evolution in Burkholderia dolosa genomes isolated from chronic infections in patients with cystic fibrosis.
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References
Lipuma, J.J. Clin. Microbiol. Rev. 23, 299–323 (2010).
Lieberman, T.D. et al. Nat. Genet. 46, 82–87 (2014).
Lieberman, T.D. et al. Nat. Genet. 43, 1275–1280 (2011).
McKeon, S.A., Nguyen, D.T., Viteri, D.F., Zlosnik, J.E. & Sokol, P.A. J. Infect. Dis. 203, 383–392 (2011).
Silva, I.N. et al. Microbiology 157, 3124–3137 (2011).
Yang, L., Jelsbak, L. & Molin, S. Environ. Microbiol. 13, 1682–1689 (2011).
Foweraker, J.E., Laughton, C.R., Brown, D.F. & Bilton, D. J. Antimicrob. Chemother. 55, 921–927 (2005).
Mowat, E. et al. Am. J. Respir. Crit. Care Med. 183, 1674–1679 (2011).
Workentine, M.L. et al. PLoS ONE 8, e60225 (2013).
Poltak, S.R. & Cooper, V.S. ISME J. 5, 369–378 (2011).
Traverse, C.C., Mayo-Smith, L.M., Poltak, S.R. & Cooper, V.S. Proc. Natl. Acad. Sci. USA 110, E250–E259 (2013).
Foweraker, J.E., Laughton, C.R., Brown, D.F. & Bilton, D. Antimicrob. Agents Chemother. 53, 4809–4815 (2009).
Holt, K.E. et al. Bioinformatics 25, 2074–2075 (2009).
Bernier, S.P. & Sokol, P.A. J. Bacteriol. 187, 5278–5291 (2005).
Loutet, S.A., Flannagan, R.S., Kooi, C., Sokol, P.A. & Valvano, M.A. J. Bacteriol. 188, 2073–2080 (2006).
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Bernier, S., Workentine, M. & Surette, M. Genetic signature of bacterial pathogen adaptation during chronic pulmonary infections. Nat Genet 46, 5–6 (2014). https://doi.org/10.1038/ng.2859
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DOI: https://doi.org/10.1038/ng.2859
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