Embryonal tumors with multilayered rosettes (ETMRs) are primitive neuroectodermal tumors arising in infants. A new study shows that these tumors are universally driven by fusion of the promoter of a gene with brain-specific expression, TTYH1, to C19MC, the largest human microRNA cluster, activating a fetal neural development program.
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Archer, T., Pomeroy, S. A developmental program drives aggressive embryonal brain tumors. Nat Genet 46, 2–3 (2014). https://doi.org/10.1038/ng.2857
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DOI: https://doi.org/10.1038/ng.2857
