A recent study in the New England Journal of Medicine reports the genomic and epigenomic changes in adult acute myeloid leukemia (AML). The patterns of somatic mutation suggest biologically relevant connections between the functional categories of genes driving AML.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Foran, J.M. Hematology Am. Soc. Hematol. Educ. Program 2010, 47–55 (2010).
Löwenberg, B. Hematology Am. Soc. Hematol. Educ. Program 2008, 1–11 (2008).
Prebet, T. et al. J. Clin. Oncol. 27, 4747–4753 (2009).
Fuchs, O. et al. Blood Cells Mol. Dis. 40, 401–405 (2008).
Ley, T.J. et al. N. Engl. J. Med. 363, 2424–2433 (2010).
Naoe, T. & Kiyoi, H. Int. J. Hematol. 97, 165–174 (2013).
Shen, Y. et al. Blood 118, 5593–5603 (2011).
Yan, X.J. et al. Nat. Genet. 43, 309–315 (2011).
Shah, M.Y. & Licht, J.D. Nat. Genet. 43, 289–290 (2011).
Thol, F. et al. J. Clin. Oncol. 29, 2889–2896 (2011).
Ribeiro, A.F. et al. Blood 119, 5824–5831 (2012).
Mardis, E.R. et al. N. Engl. J. Med. 361, 1058–1066 (2009).
Dombret, H. Blood 118, 5366–5367 (2011).
Cancer Genome Atlas Research Network. N. Engl. J. Med. published online; doi:10.1056/NEJMoa1301689 (1 May 2013).
Thiede, C. Blood 119, 5615–5617 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Supplementary Text and Figures
Supplementary Note (PDF 38 kb)
Rights and permissions
About this article
Cite this article
Chen, SJ., Shen, Y. & Chen, Z. A panoramic view of acute myeloid leukemia. Nat Genet 45, 586–587 (2013). https://doi.org/10.1038/ng.2651
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.2651
This article is cited by
-
Therapeutic potential of FLT4-targeting peptide in acute myeloid leukemia
Cancer Immunology, Immunotherapy (2023)
-
Role of chromosomal aberrations in clonal diversity and progression of acute myeloid leukemia
Leukemia (2015)
-
Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse
Frontiers of Medicine (2015)