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Reply to "The classification of intestinal polyposis"

Nature Genetics volume 45, pages 2–3 (2013)Cite this article

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Tomlinson et al. reply:

In response to our report that germline GREM1 mutations cause hereditary mixed polyposis syndrome (HMPS), Cheah and colleagues write that some families under their care have HMPS caused by germline BMPR1A mutations1,2. The original family with HMPS was SM96, described over 50 years ago at St Mark's Hospital, London, by H.J.R. Bussey. The name HMPS was used because the family had polyps of unusual and highly variable histology3, to an extent that had not previously been reported and has not been found since in families without GREM1 mutations4.

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Author information

Authors and Affiliations

  1. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    Ian Tomlinson, Emma Jaeger & Simon Leedham

  2. Family Cancer Clinic, Imperial College, St Mark's Hospital, Harrow, UK

    Huw Thomas

Authors
  1. Ian Tomlinson
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  2. Emma Jaeger
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  3. Simon Leedham
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  4. Huw Thomas
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Correspondence to Ian Tomlinson.

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Tomlinson, I., Jaeger, E., Leedham, S. et al. Reply to "The classification of intestinal polyposis". Nat Genet 45, 2–3 (2013). https://doi.org/10.1038/ng.2475

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