Although there are only 22,000 human genes, most express multiple mRNA isoforms through alternative splicing and selection of alternative 5′ and 3′ ends. A new study identifies the role of alternative splicing in maintaining neuronal excitability in the adult mouse brain.
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Cooper, T. Regulating mRNA complexity in the mammalian brain. Nat Genet 43, 618–619 (2011). https://doi.org/10.1038/ng.867
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DOI: https://doi.org/10.1038/ng.867
