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Conducting the metabolic syndrome orchestra

Nature Genetics volume 43, pages 506–508 (2011)Cite this article

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Genetic and gene expression studies have suggested an important role for KLF14 in metabolic disease. A new study now identifies a network of genes whose expression is associated with KLF14 variation in trans, providing a framework for understanding how KLF14 influences disease risk.

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Figure 1: Identification of a KLF14-associated trans regulatory network.

References

  1. Montgomery, S.B. & Dermitzakis, E.T. Nat. Rev. Genet. 12, 277–282 (2011).

    Article  CAS  Google Scholar 

  2. Schadt, E.E. et al. Nat. Genet. 37, 710–717 (2005).

    Article  CAS  Google Scholar 

  3. Musunuru, K. et al. Nature 466, 714–719 (2010).

    Article  CAS  Google Scholar 

  4. Romanoski, C.E. et al. Am. J. Hum. Genet. 86, 399–410 (2010).

    Article  CAS  Google Scholar 

  5. Small, K.S. et al. Nat. Genet. 43, 561–564 (2011).

    Article  CAS  Google Scholar 

  6. Lusis, A.J., Attie, A.D. & Reue, K. Nat. Rev. Genet. 9, 819–830 (2008).

    Article  CAS  Google Scholar 

  7. Teslovich, T.M. et al. Nature 466, 707–713 (2010).

    Article  CAS  Google Scholar 

  8. Voight, B.F. et al. Nat. Genet. 42, 579–589 (2010).

    Article  CAS  Google Scholar 

  9. Nakauchi, J. et al. Neurosci. Lett. 287, 231–235 (2000).

    Article  CAS  Google Scholar 

  10. McConnell, B.B. & Yang, V.W. Physiol. Rev. 90, 1337–1381 (2010).

    Article  CAS  Google Scholar 

  11. Parker-Katiraee, L. et al. PLoS Genet. 3, e65 (2007).

    Article  Google Scholar 

  12. Gregg, C. et al. Science 329, 643–648 (2010).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Mete Civelek and Aldons J. Lusis are in the Department of Human Genetics, the Department of Microbiology, and the Department of Medicine, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.,

    Mete Civelek & Aldons J Lusis

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  1. Mete Civelek
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  2. Aldons J Lusis
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Correspondence to Aldons J Lusis.

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The authors declare no competing financial interests.

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Civelek, M., Lusis, A. Conducting the metabolic syndrome orchestra. Nat Genet 43, 506–508 (2011). https://doi.org/10.1038/ng.842

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