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Volume 43 Issue 5, May 2011

Cover art: ramie 1 by Elizabeth Gourlay from eo art lab http://eoartlab.com/

Editorial

  • More data than we can handle is no excuse to give up our efforts to promote data access, but it may make us think about new ways to make it sustainable.

    Editorial

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Correspondence

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News & Views

  • Identifying causal variants for complex traits and understanding their function remain arduous tasks. A new study combines the advantages of gene mapping in livestock with elegant genetic and functional analyses to address these challenges and identifies candidate regulatory variants affecting stature in cattle.

    • Peter M Visscher
    • Michael E Goddard
    News & Views
  • A study characterizes the in vitro replicative capacity of over 70,000 clinical isolates of HIV-1 in the absence of drugs, or in the presence of one of 15 individual drugs. The largest survey of the effects of mutations on fitness undertaken in any organism, this study finds extensive pairwise interactions among over 1,800 variable sites identified through sequencing the protease and reverse transcriptase genes.

    • Daniel M Weinreich
    News & Views
  • Current models of Mycobacterium tuberculosis latency presume very low mycobacterial replication and mutation rates. In contrast to these models, a study reporting whole-genome sequencing of mycobacteria isolated from infected macaques shows that the mutational capacity of M. tuberculosis during latency is not reduced, a finding with important implications for tuberculosis research and control.

    • David R Sherman
    • Sebastien Gagneux
    News & Views
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Research Highlights

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Article

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Letter

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Technical Report

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Corrigendum

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