A new study successfully applies complementary whole-genome sequencing and imputation approaches to establish robust disease associations in an isolated population. This strategy is poised to help elucidate the role of variants at the low end of the allele frequency spectrum in the genetic architecture of complex traits.
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References
Holm, H. et al. Nat. Genet. 43, 316–320 (2011).
1000 Genomes Project Consortium et al. Nature 467, 1061–1073 (2010).
Kong, A. et al. Nat. Genet. 40, 1068–1075 (2008).
Le, S.Q. & Durbin, R. Genome Res. published online, doi:10.1101/gr.113084.110 (27 October 2010).
Asimit, J. & Zeggini, E. Annu. Rev. Genet. 44, 293–308 (2010).
Peltonen, L., Palotie, A. & Lange, K. Nat. Rev. Genet. 1, 182–190 (2000).
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Zeggini, E. Next-generation association studies for complex traits. Nat Genet 43, 287–288 (2011). https://doi.org/10.1038/ng0411-287
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DOI: https://doi.org/10.1038/ng0411-287
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