Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

Journal name:
Nature Genetics
Volume:
43,
Pages:
345–349
Year published:
DOI:
doi:10.1038/ng.783
Received
Accepted
Published online

Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00 × 10−3, stage 2 validation; P = 3.00 × 10−3, P = 1.19 × 10−8 and P = 4.00 × 10−3 in three independent stage 3 replication populations; P = 4.87 × 10−12, odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.

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Author information

  1. These authors contributed equally to this work.

    • Fan Wang,
    • Cheng-Qi Xu,
    • Qing He,
    • Jian-Ping Cai,
    • Xiu-Chun Li,
    • Dan Wang,
    • Xin Xiong,
    • Yu-Hua Liao,
    • Qiu-Tang Zeng,
    • Yan-Zong Yang &
    • Xiang Cheng

Affiliations

  1. Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China.

    • Fan Wang,
    • Cheng-Qi Xu,
    • Xiu-Chun Li,
    • Dan Wang,
    • Xin Xiong,
    • Cong Li,
    • Rong Yang,
    • Chu-Chu Wang,
    • Qiu-Lun Lu,
    • Ying Bai,
    • Yu-Feng Huang,
    • Dan Yin,
    • Qing Yang,
    • Xiao-Jing Wang,
    • Si-Si Li,
    • Yuan-Yuan Zhao,
    • Fen-Fen Fu,
    • Yuan Huang,
    • Nan Wang,
    • Chun-Yan Luo,
    • Li-Ying Ji,
    • Lei Li,
    • Hui Liu,
    • Er-Wen Huang,
    • Jin Cui,
    • Xiang Ren,
    • Hui Li,
    • Tie Ke,
    • Xian-Qin Zhang,
    • Jing-Yu Liu,
    • Mu-Gen Liu,
    • Li-Song Shi,
    • Xin Tu &
    • Qing K Wang
  2. Beijing Hospital, Ministry of Health, Beijing, China.

    • Qing He,
    • Jian-Ping Cai,
    • Da-Peng Dai &
    • Na Jia
  3. Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

    • Yu-Hua Liao,
    • Qiu-Tang Zeng &
    • Xiang Cheng
  4. First Affiliated Hospital of Dalian Medical University, Dalian, China.

    • Yan-Zong Yang,
    • Rong-Feng Zhang,
    • Lian-Jun Gao &
    • Yun-Long Xia
  5. Renmin Hospital of Wuhan University, Wuhan, China.

    • Gang Wu,
    • Hao Xia &
    • Bo Yang
  6. Zhongnan Hospital of Wuhan University, Wuhan, China.

    • Jing Wan &
    • Jiang-Hua Ren
  7. Affiliated Hospital of Jining Medical Collage, Shandong, China.

    • Qing-Xian Li,
    • Sheng-Wei Shi &
    • Nan Lin
  8. Department of Pharmacology, Harbin Medical University, Harbin, China.

    • Zhen-Wei Pan
  9. The First Affiliated Hospital, Harbin Medical University, Harbin, China.

    • Yue Li
  10. The Second Affiliated Hospital, Harbin Medical University, Harbin, China.

    • Bo Yu
  11. The First Hospital of Wuhan City, Wuhan, China.

    • Yan-Xia Wu,
    • Yu-He Ke &
    • Jian Lei

Contributions

Study concept and design: Q.K.W., J.-P.C., X.T., Q.H. and M.-G.L.

Acquisition of data: C.-Q.X., Q.H., J.-P.C., X.-C.L., D.W., X.X., Y.-H.L., Q.-T.Z., X.C., Y.-Z.Y., C.L., R.Y., C.-C.W., G.W., Q.-L.L., Y.B., Y.-F.H., D.Y., Q.Y., X.-J.W., D.-P.D., R.-F.Z., J.W., J.-H.R., S.-S.L., Y.-Y.Z., F.-F.F., Y.H., Q.-X.L., S.-W.S., N.L., Z.-W.P., Y.L., B.Y., Y.-X.W., Y.-H.K., J.L., N.W., C.-Y.L., L.-Y.J., L.-J.G., L.L., H. Liu, E.-W.H., J.C., N.J., X.R., H. Li, T.K., X.-Q.Z., J.-Y.L., H.X., B.Y., L.-S.S. and Y.-L.X.

Analysis and interpretation of data: C.-Q.X., F.W., D.-P.D., J.-P.C., L.-S.S., X.-C.L., D.W., X.X., Q.H., X.T. and Q.K.W.

Drafting of the manuscript: C.-Q.X., F.W. and X.T.

Critical revision of the manuscript: Q.K.W., F.W. and C.-Q.X.

Statistical analysis: F.W. and C.-Q.X.

Study supervision: Q.K.W., Q.H., J.-P.C., X.T., Y.-H.L. and Y.-Z.Y.

Competing financial interests

The authors declare no competing financial interests.

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