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TRAPing a new gene for autoimmunity

Nature Genetics volume 43, pages 90–91 (2011)Cite this article

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Two new studies show that mutations in tartrate-resistant acid phosphatase (TRAP) cause spondyloenchondrodysplasia, a rare recessive disease associated with short stature, brain calcifications and lupus-like autoimmunity. The complex clinical syndrome is probably mediated by impaired dephosphorylation of osteopontin.

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Figure 1: Mutations in TRAP lead to elevated levels of phosphorylated OPN and IFN-α.

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Authors and Affiliations

  1. Timothy W. Behrens and Robert R. Graham are in the Departments of Biomarker Discovery and Human Genetics, Genentech Inc., South San Francisco, California, USA.,

    Timothy W Behrens & Robert R Graham

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  1. Timothy W Behrens
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  2. Robert R Graham
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Correspondence to Timothy W Behrens or Robert R Graham.

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Competing interests

T.W.B. and R.R.G. are full-time employees of Genentech.

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Behrens, T., Graham, R. TRAPing a new gene for autoimmunity. Nat Genet 43, 90–91 (2011). https://doi.org/10.1038/ng0211-90

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