Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Variable evolutionary signatures at the heart of enhancers

What is the best way to identify regulatory DNA sequences such as enhancers, promoters, insulators and silencers? A new study shows that specific binding by a coactivator protein identifies enhancers that are invisible to common detection methods based on evolutionary constraint.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Binding by the transcriptional coactivator p300 identifies enhancers that are not conserved in all vertebrates.

References

  1. Dermitzakis, E.T., Reymond, A. & Antonarakis, S.E. Nat. Rev. Genet. 6, 151–157 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Pennacchio, L.A. et al. Nature 444, 499–502 (2006).

    Article  CAS  PubMed  Google Scholar 

  3. Blow, M.J. et al. Nat. Genet. 42, 806–810 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Heintzman, N.D. et al. Nat. Genet. 39, 311–318 (2007).

    Article  CAS  PubMed  Google Scholar 

  5. Birney, E. et al. Nature 447, 799–816 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. King, D.C. et al. Genome Res. 17, 775–786 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Schmidt, D. et al. Science 328, 1036–1040 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Margulies, E.H. et al. Genome Res. 17, 760–774 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ross C Hardison.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hardison, R. Variable evolutionary signatures at the heart of enhancers. Nat Genet 42, 734–735 (2010). https://doi.org/10.1038/ng0910-734

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng0910-734

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing