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Volume 42 Issue 2, February 2010

Cover Art: Finches in Blossom by Liz Toole from Cambridge Contemporary Art http://www.cambridgegallery.co.uk/

Editorial

  • Systems models and biomarker studies both pose the problem of wrangling high information content. Such publications can be made easier to review and to use if they propose explicit alternative hypotheses and show experimental exclusion of each competing explanation. In practice, we will need to be able to identify and independently cite multiple hypotheses and related experiments within a published work.

    Editorial

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News & Views

  • Advances in analytical biochemistry have recently made it possible to obtain global snapshots of metabolism. A new study couples such technology with genome-wide genetic analysis to explore inherited variation in human metabolism.

    • Vamsi K Mootha
    • Joel N Hirschhorn
    News & Views
  • Scapuloperoneal spinal muscular atrophy and Charcot-Marie-Tooth disease type 2C are inherited neurodegenerative diseases characterized by sensory defects and muscle weakness. Three new studies demonstrate that they are allelic disorders caused by mutations in the vanilloid transient receptor potential cation-channel gene TRPV4.

    • Bernd Nilius
    • Grzegorz Owsianik
    News & Views
  • A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.

    • Eva Martinez-Garcia
    • Jonathan D Licht
    News & Views
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Research Highlights

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Article

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Letter

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