Letter abstract
Nature Genetics 41, 1006 - 1010 (2009)
Published online: 16 August 2009 | doi:10.1038/ng.430
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
Elli Papaemmanuil1, Fay J Hosking1, Jayaram Vijayakrishnan1, Amy Price1, Bianca Olver1, Eammon Sheridan2, Sally E Kinsey3, Tracy Lightfoot4, Eve Roman4, Julie A E Irving5, James M Allan5, Ian P Tomlinson6, Malcolm Taylor7, Mel Greaves8 & Richard S Houlston1
To identify risk variants for childhood acute lymphoblastic leukemia (ALL), we conducted a genome-wide association study of two case-control series, analyzing the genotypes with respect to 291,423 tagging SNPs in a total of 907 ALL cases and 2,398 controls. We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 
10-19), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 10-19) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 10-7). The 10q21.2 (ARID5B) risk association appears to be selective for the subset of B-cell precursor ALL with hyperdiploidy. These data show that common low-penetrance susceptibility alleles contribute to the risk of developing childhood ALL and provide new insight into disease causation of this specific hematological cancer. Notably, all three risk variants map to genes involved in transcriptional regulation and differentiation of B-cell progenitors.
- Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
- Yorkshire Regional Genetic Service, St James's University Hospital, Beckett Street, Leeds, UK.
- Department of Paediatric and Adolescent Oncology and Haematology, St James University Hospital, Leeds, UK.
- Epidemiology and Genetics Unit, Department of Health Sciences, University of York, UK.
- Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
- Molecular and Population Genetics, Wellcome Trust Centre for Human Genetics, Oxford, UK.
- Cancer Immunogenetics Group, School of Cancer Sciences, University of Manchester, St Mary's Hospital, Manchester, UK.
- Section of Haemato-oncology, Institute of Cancer Research, Sutton, Surrey, UK.
Correspondence to: Richard S Houlston1 e-mail: richard.houlston@icr.ac.uk
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21Nature Genetics Letter (01 Feb 2009)
Genome-wide association study identifies five susceptibility loci for gliomaNature Genetics Letter (01 Aug 2009)
Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphomaNature Genetics Brief Communication (01 Aug 2009)
A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinomaJournal of Human Genetics Original Article
See all 59 matches for Research
