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Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma

Nature Genetics volume 41, pages 873–875 (2009)Cite this article

Abstract

We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 × 10−11). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).

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Figure 1: P-values for association testing of SNPs in the 6p21.33 region.

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References

  1. Morton, L.M. et al. Etiologic heterogeneity among non-Hodgkin lymphoma subtypes. Blood 112, 5150–5160 (2008).

    Article  CAS  Google Scholar 

  2. Skibola, C.F., Curry, J.D. & Nieters, A. Haematologica 92, 960–969 (2007).

    Article  CAS  Google Scholar 

  3. Skibola, C.F. et al. PLoS ONE 3, e2816 (2008).

    Article  Google Scholar 

  4. Salari, K. et al. Genet. Epidemiol. 29, 76–86 (2005).

    Article  Google Scholar 

  5. Homer, N. et al. Bioinformatics 24, 1896–1902 (2008).

    Article  CAS  Google Scholar 

  6. Becker, N., Deeg, E. & Nieters, A. Leuk. Res. 28, 713–724 (2004).

    Article  Google Scholar 

  7. Skibola, C.F. et al. Cancer Epidemiol. Biomarkers Prev. 13, 779–786 (2004).

    CAS  PubMed  Google Scholar 

  8. Spinelli, J.J. et al. Int. J. Cancer 121, 2767–2775 (2007).

    Article  CAS  Google Scholar 

  9. Nair, R.P. et al. Am. J. Hum. Genet. 78, 827–851 (2006).

    Article  CAS  Google Scholar 

  10. Nair, B., Raval, G. & Mehta, P. Am. J. Hematol. 82, 1022–1024 (2007).

    Article  CAS  Google Scholar 

  11. Su, A.I. et al. Proc. Natl. Acad. Sci. USA 99, 4465–4470 (2002).

    Article  CAS  Google Scholar 

  12. Di Bernardo, M.C. et al. Nat. Genet. 40, 1204–1210 (2008).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank S. Leach, J. Schuetz and A. MacArthur for assistance. This work was supported by US National Institutes of Health grants CA122663 (C.F.S.), CA104862 (M.T.S.), and CA45614, CA89745 and CA87014 (E.A.H.); the American Cancer Society (IRG-07-06401), the US National Institutes of Health (HL086528) and a charitable donation by Sylvia Chase (K.M.B.); the Stardust Foundation (D.W.C.); the Canadian Cancer Society and National Cancer Institute of Canada, and the Canadian Institutes of Health Research (J.J.S. and A.B.-W.); and the German José Carreras Leukemia Foundation (DJCLS R04/08 and R07/26f; A.N.).

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Authors and Affiliations

  1. Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA

    Christine F Skibola, Lucia Conde, Luz Agana, John D Curry, Jacques Riby, Luoping Zhang & Martyn T Smith

  2. Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA

    Paige M Bracci & Elizabeth A Holly

  3. International Computer Science Institute, Berkeley, California, USA

    Eran Halperin

  4. Translational Genomics Research Institute (TGen), Phoenix, Arizona, USA

    David W Craig, Kelly Iyadurai & Kevin M Brown

  5. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

    Nikolaus Becker & Alexandra Nieters

  6. Canada's Michael Smith Genome Sciences Center, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

    Angela Brooks-Wilson

  7. Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

    John J Spinelli

  8. Molecular Epidemiology, Center of Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany

    Alexandra Nieters

Authors
  1. Christine F Skibola
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  2. Paige M Bracci
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  4. Lucia Conde
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  5. David W Craig
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  8. Nikolaus Becker
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  9. Angela Brooks-Wilson
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  10. John D Curry
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  12. Elizabeth A Holly
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  13. Jacques Riby
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  14. Luoping Zhang
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  15. Alexandra Nieters
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  16. Martyn T Smith
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  17. Kevin M Brown
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Contributions

C.F.S., J.J.S., A.B.-W., E.A.H. and N.B. are principal investigators for the participating studies; L.A. and J.R. did DNA extraction, normalization and quality control; K.M.B. and K.I. prepared DNA pools and performed the genome scan and analysis; D.W.C., C.F.S., K.M.B., M.T.S. and L.Z. consulted on study design; L.A. undertook genotyping; J.D.C. performed expression analysis; D.W.C., P.M.B., A.N. and L.C. performed the statistical analyses; L.C. and E.H. conducted bioinformatics analyses; C.S.F., L.C. and K.M.B. wrote the manuscript.

Corresponding author

Correspondence to Christine F Skibola.

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Supplementary Figures 1–3, Supplementary Tables 1–7 and Supplementary Methods (PDF 3726 kb)

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Skibola, C., Bracci, P., Halperin, E. et al. Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Nat Genet 41, 873–875 (2009). https://doi.org/10.1038/ng.419

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