Letter abstract

Nature Genetics 41, 899 - 904 (2009)
Published online: 5 July 2009 | Corrected online: 20 July 2009 | doi:10.1038/ng.407

Genome-wide association study identifies five susceptibility loci for glioma

Sanjay Shete1,17, Fay J Hosking2,17, Lindsay B Robertson2, Sara E Dobbins2, Marc Sanson3, Beatrice Malmer4, Matthias Simon5, Yannick Marie3, Blandine Boisselier3, Jean-Yves Delattre3, Khe Hoang-Xuan3, Soufiane El Hallani3, Ahmed Idbaih3, Diana Zelenika6, Ulrika Andersson4, Roger Henriksson4, A Tommy Bergenheim7, Maria Feychting8, Stefan Lönn9, Anders Ahlbom8, Johannes Schramm5, Michael Linnebank10, Kari Hemminki11, Rajiv Kumar11, Sarah J Hepworth12, Amy Price2, Georgina Armstrong1, Yanhong Liu1, Xiangjun Gu1, Robert Yu1, Ching Lau13, Minouk Schoemaker14, Kenneth Muir15, Anthony Swerdlow14, Mark Lathrop6,16, Melissa Bondy1 & Richard S Houlston2

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To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 times 10-17), 8q24.21 (rs4295627, CCDC26; P = 2.34 times 10-18), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 times 10-15), 20q13.33 (rs6010620, RTEL1; P = 2.52 times 10-12) and 11q23.3 (rs498872, PHLDB1; P = 1.07 times 10-8). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.

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  1. Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
  2. Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK.
  3. Service de Neurologie Mazarin and UMR 975 INSERM-UPMC, GH Pitié-Salpêtrière, APHP, Paris, France.
  4. Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
  5. Neurochirurgische Universitätsklinik, Bonn, Germany.
  6. Centre National de Génotypage, IG/CEA, Evry Cedex, France.
  7. Department of Clinical Neuroscience, Umeå University, Umeå, Sweden.
  8. Institute of Environmental Medicine, Karolinska Institutet, Sweden.
  9. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  10. Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
  11. Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, Heidelberg, Germany.
  12. Centre for Epidemiology and Biostatistics, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
  13. Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
  14. Section of Epidemiology, Institute of Cancer Research, Sutton, UK.
  15. Division of Epidemiology and Public Health, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, UK.
  16. Foundation Jean Dausett-CEPH, Paris, France.
  17. These authors contributed equally to this work.

Correspondence to: Richard S Houlston2 e-mail: Richard.houlston@icr.ac.uk

Correspondence to: Melissa Bondy1 e-mail: mbondy@mdanderson.org

* In the version of this article initially published online, there were two errors in the author affiliations. For footnote 3, the correct affiliation is "Service de Neurologie Mazarin and UMR 975 INSERM-UPMC, GH Pitié-Salpêtrière, APHP, Paris, France," rather than "Service de Neurologie Mazarin et INSERM U 711, Hôpital de la Salpêtrière 47, Paris, France." For author Anders Ahlbom, the correct affiliation is footnote 8 rather than 7. These errors have been corrected for the print, PDF and HTML versions of this article.

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