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Letter

Nature Genetics 41, 843–848 (1 July 2009) | doi:10.1038/ng.392

Lin28 promotes transformation and is associated with advanced human malignancies

Srinivas R Viswanathan , John T Powers , William Einhorn , Yujin Hoshida , Tony L Ng , Sara Toffanin , Maureen O'Sullivan , Jun Lu , Letha A Phillips , Victoria L Lockhart , Samar P Shah , Pradeep S Tanwar , Craig H Mermel , Rameen Beroukhim , Mohammad Azam , Jose Teixeira , Matthew Meyerson , Timothy P Hughes , Josep M Llovet , Jerald Radich , Charles G Mullighan , Todd R Golub , Poul H Sorensen & George Q Daley

Multiple members of the let-7 family of miRNAs are often repressed in human cancers, thereby promoting oncogenesis by derepressing targets such as HMGA2, K-Ras and c-Myc. However, the mechanism by which let-7 miRNAs are coordinately repressed is unclear.