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Nature Genetics 41, 766 - 767 (2009)
doi:10.1038/ng0709-766
TET2 mutations in myelodysplasia and myeloid malignancies
Charles G Mullighan1
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Charles G. Mullighan is in the Department of Pathology, St. Jude's Research Hospital, Memphis, Tennessee, USA.
e-mail: charles.mullighan@stjude.org
Abstract
The genetic basis of myelodysplasia has long been enigmatic, with few common targets of mutation known. A new study reports common mutations in the TET2 gene in myelodysplasia and related myeloid malignancies, suggesting that TET2 has an important role in hematopoiesis and in the pathogenesis of this disease.
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