News and Views
Nature Genetics 41, 765 - 766 (2009)
doi:10.1038/ng0709-765
High marks for GWAS
Stephen Chanock1
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Stephen Chanock is at the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
e-mail: chanocks@mail.nih.gov
Abstract
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4). These studies are notable for the high effect sizes detected and the biological plausibility of the candidate genes.
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RESEARCH
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancerNature Genetics Letter (01 Jul 2009)
A genome-wide association study of testicular germ cell tumorNature Genetics Letter (01 Jul 2009)
