News and Views
Nature Genetics 41, 640 - 641 (2009)
doi:10.1038/ng0609-640
Narcolepsy and the T-cell receptor
Timothy J Vyse1
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Timothy J. Vyse is in the Rheumatology Section, Hammersmith Hospital, Imperial College London, UK
e-mail: t.vyse@imperial.ac.uk
Abstract
The etiology of the sleep disorder narcolepsy has not been firmly established, although an autoimmune pathogenesis has been proposed and is supported by a strong genetic association with the HLA. A new genome-wide association study provides further support for the autoimmune basis of narcolepsy by uncovering a robust association at the T-cell receptor alpha locus.
