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Brief Communication

Nature Genetics 41, 518–520 (1 May 2009) | doi:10.1038/ng.340

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

Lavanya H Palavalli , Todd D Prickett , John R Wunderlich , Xiaomu Wei , Allison S Burrell , Patricia Porter-Gill , Sean Davis , Chenwei Wang , Julia C Cronin , Neena S Agrawal , Jimmy C Lin , Wendy Westbroek , Shelley Hoogstraten-Miller , Alfredo A Molinolo , Patricia Fetsch , Armando C Filie , Michael P O'Connell , Carolyn E Banister , Jason D Howard , Phillip Buckhaults , Ashani T Weeraratna , Lawrence C Brody , Steven A Rosenberg & Yardena Samuels

A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity.