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Nature Genetics 41, 512 - 513 (2009)
doi:10.1038/ng0509-512
Of flaky tails and itchy skin
Donata Vercelli1
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Donata Vercelli is at the Arizona Initiative for the Biology of Complex Diseases (ABCD) and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, USA.
e-mail: donata@arc.arizona.edu
Abstract
A new study defines the flaky tail mouse as a model for human atopic dermatitis caused by a null mutation in the gene encoding filaggrin, a key component of the epidermal barrier. Research in these mice will help explain how a disrupted barrier contributes to the pathogenesis of atopic dermatitis and to asthma arising in the context of atopic skin disease.
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RESEARCH
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen primingNature Genetics Letter (01 May 2009)
Prevalent and Low-Frequency Null Mutations in the Filaggrin Gene Are Associated with Early-Onset and Persistent Atopic EczemaJournal of Investigative Dermatology Letter
Specific Filaggrin Mutations Cause Ichthyosis Vulgaris and Are Significantly Associated with Atopic Dermatitis in JapanJournal of Investigative Dermatology Original Article
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