News and Views


Nature Genetics 41, 512 - 513 (2009)
doi:10.1038/ng0509-512

Of flaky tails and itchy skin

Donata Vercelli1

  1. Donata Vercelli is at the Arizona Initiative for the Biology of Complex Diseases (ABCD) and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, USA.
    e-mail: donata@arc.arizona.edu


A new study defines the flaky tail mouse as a model for human atopic dermatitis caused by a null mutation in the gene encoding filaggrin, a key component of the epidermal barrier. Research in these mice will help explain how a disrupted barrier contributes to the pathogenesis of atopic dermatitis and to asthma arising in the context of atopic skin disease.

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