Letter abstract
Nature Genetics 41, 591 - 595 (2009)
Published online: 6 April 2009 | doi:10.1038/ng.348
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
Yoichiro Kamatani1,2, Sukanya Wattanapokayakit3, Hidenori Ochi4,5, Takahisa Kawaguchi4, Atsushi Takahashi4, Naoya Hosono4, Michiaki Kubo4, Tatsuhiko Tsunoda4, Naoyuki Kamatani4, Hiromitsu Kumada6, Aekkachai Puseenam7, Thanyachai Sura7, Yataro Daigo1,2, Kazuaki Chayama4,5, Wasun Chantratita8, Yusuke Nakamura1,4 & Koichi Matsuda1
Chronic hepatitis B is a serious infectious liver disease that often progresses to liver cirrhosis and hepatocellular carcinoma; however, clinical outcomes after viral exposure vary enormously among individuals1. Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region including HLA-DPA1 and HLA-DPB1. We validated these associations by genotyping two SNPs from the region in three additional Japanese and Thai cohorts consisting of 1,300 cases and 2,100 controls (combined P = 6.34 
10-39 and 2.31 10-38, OR = 0.57 and 0.56, respectively). Subsequent analyses revealed risk haplotypes (HLA-DPA1*0202-DPB1*0501 and HLA-DPA1*0202-DPB1*0301, OR = 1.45 and 2.31, respectively) and protective haplotypes (HLA-DPA1*0103-DPB1*0402 and HLA-DPA1*0103-DPB1*0401, OR = 0.52 and 0.57, respectively). Our findings show that genetic variants in the HLA-DP locus are strongly associated with risk of persistent infection with hepatitis B virus.
- Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
- Department of Medical Genome Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Tokyo, Japan.
- Medical Genetic Section, National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
- Center for Genomic Medicine, RIKEN, Kanagawa, Japan.
- Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
- Department of Hepatology, Toranomon Hospital, Tokyo, Japan.
- Department of Medicine, Faculty of Medicine, Ramathidi Hospital, Mahidol University, Bangkok, Thailand.
- Virology and Molecular Microbiology Unit, Department of Pathology, Faculty of Medicine, Ramathidi Hospital, Mahidol University, Bangkok, Thailand.
Correspondence to: Yusuke Nakamura1,4 e-mail: yusuke@ims.u-tokyo.ac.jp
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Expert assessment of exposure to carcinogens in Norway's offshore petroleum industryJournal of Exposure Science and Environmental Epidemiology Article Response
Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese populationNature Genetics Letter (01 Oct 2008)
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancerNature Genetics Article (01 Dec 2008)
Common variations in BARD1 influence susceptibility to high-risk neuroblastomaNature Genetics Letter (01 Jun 2009)
See all 41 matches for Research
