Myeloproliferative neoplasms are hematological malignancies frequently associated with somatically acquired mutation of the JAK2 gene. A new study shows that these mutations are preferentially found within a particular inherited JAK2 haplotype, implying the existence of a strong, but uncharacterized, interaction between somatic and germline genetics at this locus.
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References
Jones, A.V. et al. Nat. Genet. 41, 446–449 (2009).
Olcaydu, D. et al. Nat. Genet. 41, 450–454 (2009).
Kilpivaara, O. et al. Nat. Genet. 41, 455–459 (2009).
Campbell, P.J. & Green, A.R. N. Engl. J. Med. 355, 2452–2466 (2006).
Levine, R.L., Pardanani, A., Tefferi, A. & Gilliland, D.G. Nat. Rev. Cancer 7, 673–683 (2007).
Scott, L.M. et al. N. Engl. J. Med. 356, 459–468 (2007).
Pikman, Y. et al. PLoS Med. 3, e270 (2006).
Bellanne-Chantelot, C. et al. Blood 108, 346–352 (2006).
Landgren, O. et al. Blood 112, 2199–2204 (2008).
Stratton, M.R. & Rahman, N. Nat. Genet. 40, 17–22 (2008).
Barrett, J.C. et al. Nat. Genet. 40, 955–962 (2008).
Catlin, S.N., Guttorp, P. & Abkowitz, J.L. Blood 106, 2688–2692 (2005).
Campbell, P.J. et al. Proc. Natl. Acad. Sci. USA 105, 13081–13086 (2008).
Xu, X. et al. Blood 109, 339–342 (2007).
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Campbell, P. Somatic and germline genetics at the JAK2 locus. Nat Genet 41, 385–386 (2009). https://doi.org/10.1038/ng0409-385
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DOI: https://doi.org/10.1038/ng0409-385