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Nature Genetics 41, 272 - 273 (2009)
doi:10.1038/ng0309-272
FGF9 on the move
Douglas Spicer1
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Douglas Spicer is at the Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, Maine 04074, USA.
e-mail: spiced@mmc.org
Abstract
FGF receptors have been implicated in a number of syndromes that involve skeletal disorders. A new study in mice has identified a spontaneous mutation in Fgf9 with reduced activity but increased diffusion through tissues, resulting in a gain-of-function phenotype comparable to those due to activating mutations in genes encoding FGF receptors.
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