News and Views
Nature Genetics 41, 270 - 271 (2009)
doi:10.1038/ng0309-270
Processing the H3K36me3 signature
Robert J Sims III1 & Danny Reinberg2
- Robert J. Sims III is at Constellation Pharmaceuticals, Cambridge, Massachusetts 02139, USA.
-
Danny Reinberg is at the Department of Biochemistry, New York University School of Medicine, New York 10016,
USA.
e-mail: reinbd01@nyumc.org e-mail: robert.sims@constellationpharma.com
Abstract
The global patterning of histone lysine methylation has been scrutinized over the years in an effort to uncover unique features indicative of chromatin function. A study in Caenorhabditis elegans now shows that nucleosomes covering exons and introns on active genes are differentially marked by H3K36 trimethylation, suggesting a new mode of communication between chromatin and pre-mRNA processing.
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