1. Robert J. Sims III is at Constellation Pharmaceuticals, Cambridge, Massachusetts 02139, USA.
2. Danny Reinberg is at the Department of Biochemistry, New York University School of Medicine, New York 10016, USA.
   e-mail: reinbd01@nyumc.org e-mail: robert.sims@constellationpharma.com

Abstract

The global patterning of histone lysine methylation has been scrutinized over the years in an effort to uncover unique features indicative of chromatin function. A study in Caenorhabditis elegans now shows that nucleosomes covering exons and introns on active genes are differentially marked by H3K36 trimethylation, suggesting a new mode of communication between chromatin and pre-mRNA processing.

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